The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway

The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway

Abstract Background Cell death within the tumor microenvironment (TME) plays a crucial role in controlling cancer by influencing the balance of tumor-specific immunity. Cancer-associated fibroblasts (CAFs) significantly contribute to tumor progression through paracrine mechanisms. We found that repr...

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Bibliographic Details
Main Authors: Shinyoung Kim, Kyungwon Yang, Kiyoon Kim, Hee Ja Kim, Da Young Kim, Jeesoo Chae, Young-Ho Ahn, Jihee Lee Kang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
CAF
Apoptotic cancer cell
Lung cancer
WISP-1-integrin ανβ3-STAT1 signaling pathway
Tumor growth
Online Access:https://doi.org/10.1186/s12964-025-02094-2
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