Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection
Infection is the outcome of a contest between a pathogen and its host. In the disease leishmaniasis, the causative protozoan parasites are harbored inside the macrophages. Leishmania species adapt strategies to make the infection chronic, keeping a balance between their own and the host's defen...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/796235 |
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| author | Marion M. Chan Nagasuresh Adapala Cui Chen |
| author_facet | Marion M. Chan Nagasuresh Adapala Cui Chen |
| author_sort | Marion M. Chan |
| collection | DOAJ |
| description | Infection is the outcome of a contest between a pathogen and its host. In the disease leishmaniasis, the causative protozoan parasites are harbored inside the macrophages. Leishmania species adapt strategies to make the infection chronic, keeping a balance between their own and the host's defense so as to establish an environment that is favorable for survival and propagation. Activation of peroxisome proliferator-activated receptor (PPAR) is one of the tactics used. This ligand-activated nuclear factor curbs inflammation to protect the host from excessive injuries by setting a limit to its destructive force. In this paper, we report the interaction of host PPARs and the pathogen for visceral leishmaniasis, Leishmania donovani, in vivo and in vitro. PPAR expression is induced by parasitic infection. Leishmanial activation of PPARγ promotes survival, whereas blockade of PPARγ facilitates removal of the parasite. Thus, Leishmania parasites harness PPARγ to increase infectivity. |
| format | Article |
| id | doaj-art-e652fe85cb6344e0b4e2a4d51fdccf76 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-e652fe85cb6344e0b4e2a4d51fdccf762025-02-03T06:10:50ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/796235796235Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania InfectionMarion M. Chan0Nagasuresh Adapala1Cui Chen2Department of Microbiology and Immunology, Temple University School of Medicine, Room 534 OMS, 3400 North Broad Street, Philadelphia, PA 19140, USADepartment of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USAUndergraduate Research Program, College of Science and Technology, Temple University, Philadelphia, PA 19140, USAInfection is the outcome of a contest between a pathogen and its host. In the disease leishmaniasis, the causative protozoan parasites are harbored inside the macrophages. Leishmania species adapt strategies to make the infection chronic, keeping a balance between their own and the host's defense so as to establish an environment that is favorable for survival and propagation. Activation of peroxisome proliferator-activated receptor (PPAR) is one of the tactics used. This ligand-activated nuclear factor curbs inflammation to protect the host from excessive injuries by setting a limit to its destructive force. In this paper, we report the interaction of host PPARs and the pathogen for visceral leishmaniasis, Leishmania donovani, in vivo and in vitro. PPAR expression is induced by parasitic infection. Leishmanial activation of PPARγ promotes survival, whereas blockade of PPARγ facilitates removal of the parasite. Thus, Leishmania parasites harness PPARγ to increase infectivity.http://dx.doi.org/10.1155/2012/796235 |
| spellingShingle | Marion M. Chan Nagasuresh Adapala Cui Chen Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection PPAR Research |
| title | Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection |
| title_full | Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection |
| title_fullStr | Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection |
| title_short | Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection |
| title_sort | peroxisome proliferator activated receptor γ mediated polarization of macrophages in leishmania infection |
| url | http://dx.doi.org/10.1155/2012/796235 |
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