Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis
Introduction. Survival outcomes in patients with unresectable colorectal cancer (CRC) liver metastasis treated by radiofrequency ablation (RFA) combined with systemic chemotherapy and correlation with potential prognostic factors were investigated. Material and Methods. A retrospective cohort study...
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| Format: | Article |
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2020-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8836922 |
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| author | Ky Thai Doan Long Nguyễn Việt Thinh Nguyen Tien Binh Nguyen Canh Hoai Ngo Thi Ngoc Nguyen Thanh Bieu Bui Quang Quang Le Van Hyun Woong Lee Bang Mai Hong |
| author_facet | Ky Thai Doan Long Nguyễn Việt Thinh Nguyen Tien Binh Nguyen Canh Hoai Ngo Thi Ngoc Nguyen Thanh Bieu Bui Quang Quang Le Van Hyun Woong Lee Bang Mai Hong |
| author_sort | Ky Thai Doan |
| collection | DOAJ |
| description | Introduction. Survival outcomes in patients with unresectable colorectal cancer (CRC) liver metastasis treated by radiofrequency ablation (RFA) combined with systemic chemotherapy and correlation with potential prognostic factors were investigated. Material and Methods. A retrospective cohort study was conducted on 61 CRC patients with unresectable liver metastasis who underwent liver tumor-directed percutaneous RFA combined with conventional systemic chemotherapy between October 2013 and September 2018. Survival analyses were conducted using the Kaplan-Meier method, and the log-rank test was used to characterize differences in the median survival time and the 1-year, 3-year, and 5-year overall survival rates of subgroups to identify prognostic factors. Results. Median overall survival and progression-free survival of all patients were 32 and 14 months, respectively. The cumulative survival rates at 1-, 3-, and 5-years were 93.2%; 44.5%, and 38.2%, respectively. Univariate analysis revealed that pre-RFA serum CEA levels, Eastern Cooperative Oncology Group (ECOG) status, number of liver lesions, the size of the largest lesion, and the total lesion size were prognostic factors. However, multivariate analysis demonstrated that only the number of liver lesions and the size of the largest lesion were independent prognostic factors for survival. Conclusion. RFA plus systemic chemotherapy provides an encouraging survival outcome for patients with unresectable CRC liver metastasis. Multivariate analysis demonstrated that the number and size of liver metastatic lesions are independent prognostic factors for survival. |
| format | Article |
| id | doaj-art-e6507b1b08f04eed8107e2bb8cd322c2 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-e6507b1b08f04eed8107e2bb8cd322c22025-02-03T01:05:10ZengWileyInternational Journal of Hepatology2090-34482090-34562020-01-01202010.1155/2020/88369228836922Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver MetastasisKy Thai Doan0Long Nguyễn Việt1Thinh Nguyen Tien2Binh Nguyen Canh3Hoai Ngo Thi4Ngoc Nguyen Thanh5Bieu Bui Quang6Quang Le Van7Hyun Woong Lee8Bang Mai Hong9Department of Gastroenterology and Hepatology, 108 Military Central Hospital, Hanoi, VietnamDepartment of Medical Oncology, 108 Military Central Hospital, Hanoi, VietnamDepartment of Gastroenterology and Hepatology, 108 Military Central Hospital, Hanoi, VietnamDepartment of Gastroenterology and Hepatology, 108 Military Central Hospital, Hanoi, VietnamDepartment of Gastroenterology and Hepatology, 108 Military Central Hospital, Hanoi, VietnamDepartment of Medical Oncology, 108 Military Central Hospital, Hanoi, VietnamDepartment of Radiation Oncology and Radiosurgery, 108 Military Central Hospital, VietnamDepartment of Oncology, Hanoi Medical University Hospital, VietnamDepartment of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of KoreaDepartment of Gastroenterology and Hepatology, 108 Military Central Hospital, Hanoi, VietnamIntroduction. Survival outcomes in patients with unresectable colorectal cancer (CRC) liver metastasis treated by radiofrequency ablation (RFA) combined with systemic chemotherapy and correlation with potential prognostic factors were investigated. Material and Methods. A retrospective cohort study was conducted on 61 CRC patients with unresectable liver metastasis who underwent liver tumor-directed percutaneous RFA combined with conventional systemic chemotherapy between October 2013 and September 2018. Survival analyses were conducted using the Kaplan-Meier method, and the log-rank test was used to characterize differences in the median survival time and the 1-year, 3-year, and 5-year overall survival rates of subgroups to identify prognostic factors. Results. Median overall survival and progression-free survival of all patients were 32 and 14 months, respectively. The cumulative survival rates at 1-, 3-, and 5-years were 93.2%; 44.5%, and 38.2%, respectively. Univariate analysis revealed that pre-RFA serum CEA levels, Eastern Cooperative Oncology Group (ECOG) status, number of liver lesions, the size of the largest lesion, and the total lesion size were prognostic factors. However, multivariate analysis demonstrated that only the number of liver lesions and the size of the largest lesion were independent prognostic factors for survival. Conclusion. RFA plus systemic chemotherapy provides an encouraging survival outcome for patients with unresectable CRC liver metastasis. Multivariate analysis demonstrated that the number and size of liver metastatic lesions are independent prognostic factors for survival.http://dx.doi.org/10.1155/2020/8836922 |
| spellingShingle | Ky Thai Doan Long Nguyễn Việt Thinh Nguyen Tien Binh Nguyen Canh Hoai Ngo Thi Ngoc Nguyen Thanh Bieu Bui Quang Quang Le Van Hyun Woong Lee Bang Mai Hong Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis International Journal of Hepatology |
| title | Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis |
| title_full | Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis |
| title_fullStr | Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis |
| title_full_unstemmed | Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis |
| title_short | Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis |
| title_sort | prognostic factors of radiofrequency ablation plus systemic chemotherapy for unresectable colorectal cancer with liver metastasis |
| url | http://dx.doi.org/10.1155/2020/8836922 |
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