High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Summary: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood s...
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Elsevier
2024-11-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224023915 |
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| author | Marcus Z.W. Tong Katina D. Hulme Soi Cheng Law Ellesandra Noye Emily S. Dorey Keng Yih Chew Louise C. Rowntree Carolien E. van de Sandt Katherine Kedzierska Marco Goeijenbier Katharina Ronacher Fawaz Alzaid Jean-Baptiste Julla Jean-Pierre Riveline Katie E. Lineburg Corey Smith Emma J. Grant Stephanie Gras Linda A. Gallo Helen L. Barrett Kirsty R. Short |
| author_facet | Marcus Z.W. Tong Katina D. Hulme Soi Cheng Law Ellesandra Noye Emily S. Dorey Keng Yih Chew Louise C. Rowntree Carolien E. van de Sandt Katherine Kedzierska Marco Goeijenbier Katharina Ronacher Fawaz Alzaid Jean-Baptiste Julla Jean-Pierre Riveline Katie E. Lineburg Corey Smith Emma J. Grant Stephanie Gras Linda A. Gallo Helen L. Barrett Kirsty R. Short |
| author_sort | Marcus Z.W. Tong |
| collection | DOAJ |
| description | Summary: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8+CD107a−IFNγ−MIP1β−TNF+ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes. |
| format | Article |
| id | doaj-art-e64ff09be3ce403f9aed6cdf25f703ff |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-e64ff09be3ce403f9aed6cdf25f703ff2025-08-20T02:12:14ZengElsevieriScience2589-00422024-11-01271111116610.1016/j.isci.2024.111166High glycemic variability is associated with a reduced T cell cytokine response to influenza A virusMarcus Z.W. Tong0Katina D. Hulme1Soi Cheng Law2Ellesandra Noye3Emily S. Dorey4Keng Yih Chew5Louise C. Rowntree6Carolien E. van de Sandt7Katherine Kedzierska8Marco Goeijenbier9Katharina Ronacher10Fawaz Alzaid11Jean-Baptiste Julla12Jean-Pierre Riveline13Katie E. Lineburg14Corey Smith15Emma J. Grant16Stephanie Gras17Linda A. Gallo18Helen L. Barrett19Kirsty R. Short20School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the NetherlandsMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, AustraliaMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, AustraliaDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, AustraliaDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the NetherlandsDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, AustraliaDepartment of Intensive Care, Erasmus MC, Rotterdam, the Netherlands; Department of Intensive Care, Spaarne Gasthuis, Haarlem, Hoofddorp, the NetherlandsMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, AustraliaUniversité Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Dasman Diabetes Institute, Kuwait, KuwaitUniversité Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Department of Diabetes, Clinical Investigation Centre (CIC-9504), Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris, Paris, FranceUniversité Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Department of Diabetes, Clinical Investigation Centre (CIC-9504), Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris, Paris, FranceQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Queensland Immunology Research Centre, St Lucia, QLD, AustraliaDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Bundoora, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Clayton, VIC, AustraliaDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Bundoora, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Clayton, VIC, AustraliaSchool of Health and Behavioural Sciences, University of the Sunshine Coast, Petrie, QLD, AustraliaMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; University of New South Wales Medicine, Kensington, NSW, Australia; Obstetric Medicine, Royal Hospital for Women, Randwick, NSW, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, Australia; Queensland Immunology Research Centre, St Lucia, QLD, Australia; Corresponding authorSummary: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8+CD107a−IFNγ−MIP1β−TNF+ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.http://www.sciencedirect.com/science/article/pii/S2589004224023915EndocrinologyHuman metabolism |
| spellingShingle | Marcus Z.W. Tong Katina D. Hulme Soi Cheng Law Ellesandra Noye Emily S. Dorey Keng Yih Chew Louise C. Rowntree Carolien E. van de Sandt Katherine Kedzierska Marco Goeijenbier Katharina Ronacher Fawaz Alzaid Jean-Baptiste Julla Jean-Pierre Riveline Katie E. Lineburg Corey Smith Emma J. Grant Stephanie Gras Linda A. Gallo Helen L. Barrett Kirsty R. Short High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus iScience Endocrinology Human metabolism |
| title | High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus |
| title_full | High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus |
| title_fullStr | High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus |
| title_full_unstemmed | High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus |
| title_short | High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus |
| title_sort | high glycemic variability is associated with a reduced t cell cytokine response to influenza a virus |
| topic | Endocrinology Human metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224023915 |
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