Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months
Adult women (n=113) and men (n=100) initiating combination antiretroviral therapy (cART) and women not yet eligible for cART (n=199) in Kigali, Rwanda, were followed for 6–24 months between 2007 and 2010. In the cART groups, 21% of patients required a drug change due to side effects and 11% of patie...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2015/740212 |
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| author | Brenda Asiimwe-Kateera Nienke Veldhuijzen Jean Paul Balinda John Rusine Sally Eagle Joseph Vyankandondera Julie Mugabekazi Pascale Ondoa Kimberly Boer Anita Asiimwe Joep Lange Peter Reiss Janneke van de Wijgert |
| author_facet | Brenda Asiimwe-Kateera Nienke Veldhuijzen Jean Paul Balinda John Rusine Sally Eagle Joseph Vyankandondera Julie Mugabekazi Pascale Ondoa Kimberly Boer Anita Asiimwe Joep Lange Peter Reiss Janneke van de Wijgert |
| author_sort | Brenda Asiimwe-Kateera |
| collection | DOAJ |
| description | Adult women (n=113) and men (n=100) initiating combination antiretroviral therapy (cART) and women not yet eligible for cART (n=199) in Kigali, Rwanda, were followed for 6–24 months between 2007 and 2010. In the cART groups, 21% of patients required a drug change due to side effects and 11% of patients had virological failure (defined as >1,000 HIV RNA copies/mL) after 12 months of cART. About a third of the pregnancies since HIV diagnosis were unintended. The proportion of women in the pre-cART group using modern contraception other than condoms (50%) was similar to women in the general population, but this proportion was only 25% in women initiating cART. Of the women who carried at least one pregnancy to term since having been diagnosed HIV-positive, a third reported to have participated in a prevention-of-mother-to-child-transmission (PMTCT, option A) intervention. Many patients were coinfected with herpes simplex virus type 2 (79–92%), human papillomavirus (38–53%), and bacterial sexually transmitted infections (STIs) with no differences between groups. We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population. |
| format | Article |
| id | doaj-art-e647e360babb4c339f7409a40735f884 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-e647e360babb4c339f7409a40735f8842025-02-03T06:07:55ZengWileyAIDS Research and Treatment2090-12402090-12592015-01-01201510.1155/2015/740212740212Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 MonthsBrenda Asiimwe-Kateera0Nienke Veldhuijzen1Jean Paul Balinda2John Rusine3Sally Eagle4Joseph Vyankandondera5Julie Mugabekazi6Pascale Ondoa7Kimberly Boer8Anita Asiimwe9Joep Lange10Peter Reiss11Janneke van de Wijgert12INTERACT Program, Kigali, RwandaAcademic Medical Center (AMC), Department of Global Health and Amsterdam Institute for Global Health and Development (AIGHD), 1105 BM Amsterdam, NetherlandsTreatment and Research for AIDS Center (TRAC-Plus), Kigali, RwandaNational Reference Laboratory, Kigali, RwandaInstitute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, UKKigali University Teaching Hospital, Kigali, RwandaKigali University Teaching Hospital, Kigali, RwandaAcademic Medical Center (AMC), Department of Global Health and Amsterdam Institute for Global Health and Development (AIGHD), 1105 BM Amsterdam, NetherlandsINTERACT Program, Kigali, RwandaMinistry of Health of Rwanda, RwandaAcademic Medical Center (AMC), Department of Global Health and Amsterdam Institute for Global Health and Development (AIGHD), 1105 BM Amsterdam, NetherlandsAcademic Medical Center (AMC), Department of Global Health and Amsterdam Institute for Global Health and Development (AIGHD), 1105 BM Amsterdam, NetherlandsAcademic Medical Center (AMC), Department of Global Health and Amsterdam Institute for Global Health and Development (AIGHD), 1105 BM Amsterdam, NetherlandsAdult women (n=113) and men (n=100) initiating combination antiretroviral therapy (cART) and women not yet eligible for cART (n=199) in Kigali, Rwanda, were followed for 6–24 months between 2007 and 2010. In the cART groups, 21% of patients required a drug change due to side effects and 11% of patients had virological failure (defined as >1,000 HIV RNA copies/mL) after 12 months of cART. About a third of the pregnancies since HIV diagnosis were unintended. The proportion of women in the pre-cART group using modern contraception other than condoms (50%) was similar to women in the general population, but this proportion was only 25% in women initiating cART. Of the women who carried at least one pregnancy to term since having been diagnosed HIV-positive, a third reported to have participated in a prevention-of-mother-to-child-transmission (PMTCT, option A) intervention. Many patients were coinfected with herpes simplex virus type 2 (79–92%), human papillomavirus (38–53%), and bacterial sexually transmitted infections (STIs) with no differences between groups. We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population.http://dx.doi.org/10.1155/2015/740212 |
| spellingShingle | Brenda Asiimwe-Kateera Nienke Veldhuijzen Jean Paul Balinda John Rusine Sally Eagle Joseph Vyankandondera Julie Mugabekazi Pascale Ondoa Kimberly Boer Anita Asiimwe Joep Lange Peter Reiss Janneke van de Wijgert Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months AIDS Research and Treatment |
| title | Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months |
| title_full | Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months |
| title_fullStr | Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months |
| title_full_unstemmed | Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months |
| title_short | Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months |
| title_sort | combination antiretroviral therapy for hiv in rwandan adults clinical outcomes and impact on reproductive health up to 24 months |
| url | http://dx.doi.org/10.1155/2015/740212 |
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