Levels of neuroactive steroids are elevated in those who develop first-onset depression early in pregnancy

Levels of neuroactive steroids are elevated in those who develop first-onset depression early in pregnancy

BackgroundAllopregnanolone (ALLO) plays a key role in the pathogenesis of postpartum depression. However, ALLO levels have been variably associated with depression during pregnancy. It is unknown if a pre-pregnancy history of major depressive disorder (MDD), which is associated with blunted neuroste...

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Bibliographic Details
Main Authors: Elizabeth S. Wenzel, Jordan C. Barone, Tory A. Eisenlohr-Moul, Suzanne Alvernaz, Beatriz Peñalver Bernabé, Luca Spiro Santovito, Ibrahim M. M. Gdyana, Graziano Pinna, Pauline M. Maki
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Psychiatry
Subjects:
neuroactive steroids
perinatal depression
allopregnanolone
antenatal depression
pregnancy
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1557560/full
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