Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis

Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis

Abstract Advances in bladder cancer (BCa) treatment have been hampered by the lack of predictive biomarkers and targeted therapies. Here, we demonstrate that loss of the tumor suppressor NUMB promotes aggressive bladder tumorigenesis and worsens disease outcomes. Retrospective cohort studies show th...

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Bibliographic Details
Main Authors: F. A. Tucci, R. Pennisi, D. C. Rigiracciolo, M. G. Filippone, R. Bonfanti, F. Romeo, S. Freddi, E. Guerrera, C. Soriani, S. Rodighiero, R. H. Gunby, G. Jodice, F. Sanguedolce, G. Renne, N. Fusco, P. P. Di Fiore, G. Pruneri, G. Bertalot, G. Musi, G. Vago, D. Tosoni, S. Pece
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54246-6
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