Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population
Background. The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes. Methods. In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of S...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/4874121 |
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| author | Jie Wang Yu Pei Kang Chen Wenhua Yan Anping Wang Yijun Li Jia Li Haibing Wang Ping An Linxi Zhang Yingnan Ye Xinye Jin Guang Ning Yiming Mu Weijun Gu |
| author_facet | Jie Wang Yu Pei Kang Chen Wenhua Yan Anping Wang Yijun Li Jia Li Haibing Wang Ping An Linxi Zhang Yingnan Ye Xinye Jin Guang Ning Yiming Mu Weijun Gu |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Background. The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes. Methods. In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of Shijingshan district, Beijing, China, were included in our study. They were divided into three groups according to the number of childbirths, and the change in pulse wave velocity (PWV) was as an indicator of the progression of atherosclerosis because the increased PWV reflected the more serious atherosclerosis. After 3 years, we conducted follow-up visits to the subjects. Logistical regression analyses were applied to investigate the relationship between the number of childbirths and the progression of atherosclerotic stiffness and a stratification analysis was performed for history of hypertension and diabetes. Results. After 3-year follow-up, among women with diabetes, the OR of women with 2 childbirths was significant [3.5 (95% confidence interval 1.5, 7.9)] in model I, [3.1 (95% confidence interval 1.3, 7.2)] in model II, and the OR of women with ≥3 childbirths was significant [4.4 (95% confidence interval 1.3, 14.5)] in model I, [4.1 (95% confidence interval 1.2, 14.3)] in model II. Among women with hypertension, the risk of the progress of atherosclerosis was not significant. Conclusion. The increasing number of childbirths is associated with the progression of atherosclerotic stiffness among Chinese women with diabetes, independent of a variety of confounding factors. |
| format | Article |
| id | doaj-art-e6287bc51826488c87ce2bfa54a28023 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e6287bc51826488c87ce2bfa54a280232025-02-03T05:59:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/48741214874121Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese PopulationJie Wang0Yu Pei1Kang Chen2Wenhua Yan3Anping Wang4Yijun Li5Jia Li6Haibing Wang7Ping An8Linxi Zhang9Yingnan Ye10Xinye Jin11Guang Ning12Yiming Mu13Weijun Gu14School of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, ChinaShanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaBackground. The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes. Methods. In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of Shijingshan district, Beijing, China, were included in our study. They were divided into three groups according to the number of childbirths, and the change in pulse wave velocity (PWV) was as an indicator of the progression of atherosclerosis because the increased PWV reflected the more serious atherosclerosis. After 3 years, we conducted follow-up visits to the subjects. Logistical regression analyses were applied to investigate the relationship between the number of childbirths and the progression of atherosclerotic stiffness and a stratification analysis was performed for history of hypertension and diabetes. Results. After 3-year follow-up, among women with diabetes, the OR of women with 2 childbirths was significant [3.5 (95% confidence interval 1.5, 7.9)] in model I, [3.1 (95% confidence interval 1.3, 7.2)] in model II, and the OR of women with ≥3 childbirths was significant [4.4 (95% confidence interval 1.3, 14.5)] in model I, [4.1 (95% confidence interval 1.2, 14.3)] in model II. Among women with hypertension, the risk of the progress of atherosclerosis was not significant. Conclusion. The increasing number of childbirths is associated with the progression of atherosclerotic stiffness among Chinese women with diabetes, independent of a variety of confounding factors.http://dx.doi.org/10.1155/2019/4874121 |
| spellingShingle | Jie Wang Yu Pei Kang Chen Wenhua Yan Anping Wang Yijun Li Jia Li Haibing Wang Ping An Linxi Zhang Yingnan Ye Xinye Jin Guang Ning Yiming Mu Weijun Gu Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population International Journal of Endocrinology |
| title | Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population |
| title_full | Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population |
| title_fullStr | Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population |
| title_full_unstemmed | Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population |
| title_short | Association between the Number of Childbirths and the Progress of Atherosclerosis among Women with Diabetes: A Cohort Study Based on Chinese Population |
| title_sort | association between the number of childbirths and the progress of atherosclerosis among women with diabetes a cohort study based on chinese population |
| url | http://dx.doi.org/10.1155/2019/4874121 |
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