Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations
Speculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago. But still, conclusive evidence that adult neurogenesis contributes to antidepressive...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/723915 |
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| author | Peter Rotheneichner Simona Lange Anna O’Sullivan Julia Marschallinger Pia Zaunmair Christian Geretsegger Ludwig Aigner Sebastien Couillard-Despres |
| author_facet | Peter Rotheneichner Simona Lange Anna O’Sullivan Julia Marschallinger Pia Zaunmair Christian Geretsegger Ludwig Aigner Sebastien Couillard-Despres |
| author_sort | Peter Rotheneichner |
| collection | DOAJ |
| description | Speculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago. But still, conclusive evidence that adult neurogenesis contributes to antidepressive effects of pharmacological and physical therapies has not been generated yet. This review revisits recent findings on the close relation between the mode(s) of action of electroconvulsive therapy (ECT), a powerful intervention used as second-line treatment of major depression disorders, and the neurogenic response to ECT. Following application of electroconvulsive shocks, intricate interactions between neurogenesis, angiogenesis, and microglia activation, the hypothalamic-pituitary-adrenal axis and the secretion of neurotrophic factors have been documented. Furthermore, considering the fact that neurogenesis strongly diminishes along aging, we investigated the response to electroconvulsive shocks in young as well as in aged cohorts of mice. |
| format | Article |
| id | doaj-art-e6287508cd654c1d9de170e667cfbd49 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e6287508cd654c1d9de170e667cfbd492025-02-03T06:00:37ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/723915723915Hippocampal Neurogenesis and Antidepressive Therapy: Shocking RelationsPeter Rotheneichner0Simona Lange1Anna O’Sullivan2Julia Marschallinger3Pia Zaunmair4Christian Geretsegger5Ludwig Aigner6Sebastien Couillard-Despres7Paracelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaParacelsus Medical University, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaParacelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaParacelsus Medical University, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaParacelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaUniversity Clinics of Psychiatry and Psychotherapy I, Paracelsus Medical University, Ignaz-Harrer-Straße 79, 5020 Salzburg, AustriaParacelsus Medical University, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaParacelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, AustriaSpeculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago. But still, conclusive evidence that adult neurogenesis contributes to antidepressive effects of pharmacological and physical therapies has not been generated yet. This review revisits recent findings on the close relation between the mode(s) of action of electroconvulsive therapy (ECT), a powerful intervention used as second-line treatment of major depression disorders, and the neurogenic response to ECT. Following application of electroconvulsive shocks, intricate interactions between neurogenesis, angiogenesis, and microglia activation, the hypothalamic-pituitary-adrenal axis and the secretion of neurotrophic factors have been documented. Furthermore, considering the fact that neurogenesis strongly diminishes along aging, we investigated the response to electroconvulsive shocks in young as well as in aged cohorts of mice.http://dx.doi.org/10.1155/2014/723915 |
| spellingShingle | Peter Rotheneichner Simona Lange Anna O’Sullivan Julia Marschallinger Pia Zaunmair Christian Geretsegger Ludwig Aigner Sebastien Couillard-Despres Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations Neural Plasticity |
| title | Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations |
| title_full | Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations |
| title_fullStr | Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations |
| title_full_unstemmed | Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations |
| title_short | Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations |
| title_sort | hippocampal neurogenesis and antidepressive therapy shocking relations |
| url | http://dx.doi.org/10.1155/2014/723915 |
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