Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography
The current research approaches the retinal microvasculature of healthy volunteers (17 subjects), patients with diabetes mellitus without retinopathy (19 subjects), and of diabetic patients with nonproliferative (17 subjects) and proliferative (21 subjects) diabetic retinopathy, by using adaptive op...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/1516668 |
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| author | Florian Baltă Irina-Elena Cristescu Andrada-Elena Mirescu George Baltă Mihail Zemba Ioana Teodora Tofolean |
| author_facet | Florian Baltă Irina-Elena Cristescu Andrada-Elena Mirescu George Baltă Mihail Zemba Ioana Teodora Tofolean |
| author_sort | Florian Baltă |
| collection | DOAJ |
| description | The current research approaches the retinal microvasculature of healthy volunteers (17 subjects), patients with diabetes mellitus without retinopathy (19 subjects), and of diabetic patients with nonproliferative (17 subjects) and proliferative (21 subjects) diabetic retinopathy, by using adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography. For each imaging technique, several vascular parameters have been calculated in order to achieve a comparative analysis of these imaging biomarkers between the four studied groups. The results suggest that diabetic patients with or without diabetic retinopathy prove signs of retinal arteriole structural alterations, mainly showed by altered values of wall to lumen ratio, calculated for the superior or inferior temporal branch of the central retinal artery, near the optic nerve head, and significant changes of the vascular density in the retinal superficial capillary plexus. Both adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography are providing useful information about the retinal microvasculature from early onset of diabetic disease, having a promising diagnostic and prognostic role in the future. |
| format | Article |
| id | doaj-art-e60b4f4a04d74388a6f60bc5fe9e65c2 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e60b4f4a04d74388a6f60bc5fe9e65c22025-02-03T06:11:19ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/1516668Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence AngiographyFlorian Baltă0Irina-Elena Cristescu1Andrada-Elena Mirescu2George Baltă3Mihail Zemba4Ioana Teodora Tofolean5“Carol Davila” University of Medicine and Pharmacy“Retina” ClinicClinical Emergency Eye HospitalClinical Emergency Eye Hospital“Carol Davila” University of Medicine and Pharmacy“Carol Davila” University of Medicine and PharmacyThe current research approaches the retinal microvasculature of healthy volunteers (17 subjects), patients with diabetes mellitus without retinopathy (19 subjects), and of diabetic patients with nonproliferative (17 subjects) and proliferative (21 subjects) diabetic retinopathy, by using adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography. For each imaging technique, several vascular parameters have been calculated in order to achieve a comparative analysis of these imaging biomarkers between the four studied groups. The results suggest that diabetic patients with or without diabetic retinopathy prove signs of retinal arteriole structural alterations, mainly showed by altered values of wall to lumen ratio, calculated for the superior or inferior temporal branch of the central retinal artery, near the optic nerve head, and significant changes of the vascular density in the retinal superficial capillary plexus. Both adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography are providing useful information about the retinal microvasculature from early onset of diabetic disease, having a promising diagnostic and prognostic role in the future.http://dx.doi.org/10.1155/2022/1516668 |
| spellingShingle | Florian Baltă Irina-Elena Cristescu Andrada-Elena Mirescu George Baltă Mihail Zemba Ioana Teodora Tofolean Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography Journal of Diabetes Research |
| title | Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography |
| title_full | Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography |
| title_fullStr | Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography |
| title_full_unstemmed | Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography |
| title_short | Investigation of Retinal Microcirculation in Diabetic Patients Using Adaptive Optics Ophthalmoscopy and Optical Coherence Angiography |
| title_sort | investigation of retinal microcirculation in diabetic patients using adaptive optics ophthalmoscopy and optical coherence angiography |
| url | http://dx.doi.org/10.1155/2022/1516668 |
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