Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies
Introduction and Purpose:Premature ejaculation (PE) is a common male sexual disorder with a complex etiology involving psychological, neurobiological, and physiological factors. PE is defined as ejaculation occurring earlier than desired, often causing distress. Its etiology is multifactorial and no...
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| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-07-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/61308 |
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| author | Paula Bętkowska Daria Krzyżanowska Magdalena Strzelczyk Iwona Koziołek Joanna Wziątek Gabriela Pabis Wiktoria Fatyga Patrycja Fatyga Piotr Kowalik Kinga Dowierciał |
| author_facet | Paula Bętkowska Daria Krzyżanowska Magdalena Strzelczyk Iwona Koziołek Joanna Wziątek Gabriela Pabis Wiktoria Fatyga Patrycja Fatyga Piotr Kowalik Kinga Dowierciał |
| author_sort | Paula Bętkowska |
| collection | DOAJ |
| description | Introduction and Purpose:Premature ejaculation (PE) is a common male sexual disorder with a complex etiology involving psychological, neurobiological, and physiological factors. PE is defined as ejaculation occurring earlier than desired, often causing distress. Its etiology is multifactorial and not fully understood. Current standard treatments such as Selective Serotonin Reuptake Inhibitors (SSRIs) and lidocaine-prilocaine creams are helpful but limited, prompting interest in alternatives.
This review presents alternative pharmacological treatments for PE, excluding SSRIs and topical anesthetics, along with their side effects and benefits.
Material and Methods:This narrative review evaluated pharmacological treatments for PE, excluding SSRIs and topical agents. Literature was searched in databases like PubMed and ScienceDirect for English-language studies published between 2000 and 2025. Selected studies focused on agents such as tramadol, clomipramine, levosulpiride, phosphodiesterase type 5 inhibitors, and α₁-adrenoreceptor antagonists. Inclusion criteria comprised clinical trials, meta-analyses, observational studies, and systematic reviews. Studies focusing solely on SSRIs, local treatments, or non-pharmacological methods were excluded.
Results:Agents like PDE5 inhibitors, tramadol, silodosin, levosulpiride, and clomipramine showed significant improvements in intravaginal ejaculatory latency time (IELT), patient satisfaction, and outcomes, with acceptable side effect profiles.
Conclusions:PE treatment should be tailored to individual needs. PDE5Is, α₁-adrenoreceptor antagonists, tramadol, levosulpiride, and clomipramine have shown promising results; however, due to the limitations of current studies, further research is necessary to confirm their efficacy and clarify their clinical roles.
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| format | Article |
| id | doaj-art-e60706c5dc32476794d1bddc19f36e1e |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-e60706c5dc32476794d1bddc19f36e1e2025-08-20T03:28:24ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-07-014310.12775/QS.2025.43.61308Alternative Treatments for Premature Ejaculation: A Review of Pharmacological StrategiesPaula Bętkowska0https://orcid.org/0009-0002-7050-4039Daria Krzyżanowska1https://orcid.org/0009-0002-5349-5679Magdalena Strzelczyk2https://orcid.org/0009-0005-6312-3002Iwona Koziołek3https://orcid.org/0009-0002-1077-3640Joanna Wziątek4https://orcid.org/0009-0002-1656-7477Gabriela Pabis5https://orcid.org/0009-0002-3208-5160Wiktoria Fatyga6https://orcid.org/0009-0000-5931-925XPatrycja Fatyga7https://orcid.org/0009-0001-1277-1246Piotr Kowalik8https://orcid.org/0009-0009-4813-9742Kinga Dowierciał9https://orcid.org/0009-0000-9132-1026Miejskie Centrum Medyczne im. dr Karola Jonschera ŁódźMunicipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 Łódź, Poland Municipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 Łódź, Poland The Provincial Hospital, Grunwaldzka 45, 25-736 Kielce, PolandMunicipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 ŁódźThe Provincial Hospital, Grunwaldzka 45, 25-736 Kielce, Poland Non-public Health Care Facility Prophylactics Wiesława Piotrowska Limited Liability Company, Jana Jeziorańskiego 137, 25-432 Kielce, Poland The Provincial Hospital, Grunwaldzka 45, Grunwaldzka 45, 25-736 Kielce, PolandMedical University of Lodz Tadeusz Kosciuszko Avenue 4 ,90–419 Lodz Independent Public Regional Specialist Hospital in Chełm Ceramiczna 1 Street, 22-100 Chełm, Poland Introduction and Purpose:Premature ejaculation (PE) is a common male sexual disorder with a complex etiology involving psychological, neurobiological, and physiological factors. PE is defined as ejaculation occurring earlier than desired, often causing distress. Its etiology is multifactorial and not fully understood. Current standard treatments such as Selective Serotonin Reuptake Inhibitors (SSRIs) and lidocaine-prilocaine creams are helpful but limited, prompting interest in alternatives. This review presents alternative pharmacological treatments for PE, excluding SSRIs and topical anesthetics, along with their side effects and benefits. Material and Methods:This narrative review evaluated pharmacological treatments for PE, excluding SSRIs and topical agents. Literature was searched in databases like PubMed and ScienceDirect for English-language studies published between 2000 and 2025. Selected studies focused on agents such as tramadol, clomipramine, levosulpiride, phosphodiesterase type 5 inhibitors, and α₁-adrenoreceptor antagonists. Inclusion criteria comprised clinical trials, meta-analyses, observational studies, and systematic reviews. Studies focusing solely on SSRIs, local treatments, or non-pharmacological methods were excluded. Results:Agents like PDE5 inhibitors, tramadol, silodosin, levosulpiride, and clomipramine showed significant improvements in intravaginal ejaculatory latency time (IELT), patient satisfaction, and outcomes, with acceptable side effect profiles. Conclusions:PE treatment should be tailored to individual needs. PDE5Is, α₁-adrenoreceptor antagonists, tramadol, levosulpiride, and clomipramine have shown promising results; however, due to the limitations of current studies, further research is necessary to confirm their efficacy and clarify their clinical roles. https://apcz.umk.pl/QS/article/view/61308premature ejaculationerectile dysfunctiontreatmentdefinition |
| spellingShingle | Paula Bętkowska Daria Krzyżanowska Magdalena Strzelczyk Iwona Koziołek Joanna Wziątek Gabriela Pabis Wiktoria Fatyga Patrycja Fatyga Piotr Kowalik Kinga Dowierciał Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies Quality in Sport premature ejaculation erectile dysfunction treatment definition |
| title | Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies |
| title_full | Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies |
| title_fullStr | Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies |
| title_full_unstemmed | Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies |
| title_short | Alternative Treatments for Premature Ejaculation: A Review of Pharmacological Strategies |
| title_sort | alternative treatments for premature ejaculation a review of pharmacological strategies |
| topic | premature ejaculation erectile dysfunction treatment definition |
| url | https://apcz.umk.pl/QS/article/view/61308 |
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