Hyaluronic Acid Inhibits Polycation Induced Cellular Responses
Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000396 |
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| Summary: | Positively charged macromolecules cause a variety of pathological
events through their electrostatic interaction with anionic sites
present on the membrane of target cells. In the present study we have
investigated the effect of hyaluronic acid, a negatively charged
molecule, on rat paw oedema induced by poly-L-lysine as well as on
histamine release from rat mast cells and nitric oxide formation
from rabbit aorta, both induced by this polycation. The results
indicate that hyaluronic acid is able to suppress these
poly-L-lysine induced effects with a mechanism which possibly
depends on its negative charges which may balance the effects of
positively charged polycations. |
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| ISSN: | 0962-9351 1466-1861 |