Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice
Objective: To observe the effect of Citrullus lanatus var. lanatus on albino mice model of anxiety and depression. Methodology: This experimental study was done in the Pharmacology department of Karachi University for a period of 02 months from 5th February-9th April 2016. Watermelon (Citrullus lan...
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Bahria Univerisy Health Sciences, Campus Karachi
2017-06-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/257 |
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| author | Nuzhat Sultana Shahid Ali |
| author_facet | Nuzhat Sultana Shahid Ali |
| author_sort | Nuzhat Sultana |
| collection | DOAJ |
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Objective: To observe the effect of Citrullus lanatus var. lanatus on albino mice model of anxiety and depression.
Methodology: This experimental study was done in the Pharmacology department of Karachi University for a period of 02
months from 5th February-9th April 2016. Watermelon (Citrullus lanatus var. lanatus) was used. Animals were randomly assigned
into 4 groups A, B, C and D (n=10). Group A was control (normal saline). Group B was treated with Citrullus lanatus juice in
a dose of 3 ml/kg, Group C was given 6 ml/kg of juice. Two drugs (Diazepam and Fluxetin) were used as standard and given
to group D animals. All doses were administered orally. Level of anxiety and depression among animals was tested by light/dark
box test and forced swim test. Data was analyzed statistically.
Results: Animals treated with Citrullus lanatus juice showed marked reduction in anxiety which was evident from results of
light/dark box test while forced swim test revealed no effect on depression.
Conclusion: Citrullus lanatus contains important natural anti-oxidants like lycopene and vitamin C which prevent injury to
vital organs like liver, heart and brain from toxic effects of reactive oxygen species. Arginine in Citrullus juice is also precursor
of neurotransmitters like -Aminobutyric acid (GABA) and glutamate. These results showed that Citrullus because of its
components like arginine played an important role in maintaining normal neurological function and ameliorated anxiety and
depression.
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| format | Article |
| id | doaj-art-e6023cee2db8472ebbad00f38428e511 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-e6023cee2db8472ebbad00f38428e5112025-08-20T02:45:09ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822017-06-0173Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino MiceNuzhat SultanaShahid Ali Objective: To observe the effect of Citrullus lanatus var. lanatus on albino mice model of anxiety and depression. Methodology: This experimental study was done in the Pharmacology department of Karachi University for a period of 02 months from 5th February-9th April 2016. Watermelon (Citrullus lanatus var. lanatus) was used. Animals were randomly assigned into 4 groups A, B, C and D (n=10). Group A was control (normal saline). Group B was treated with Citrullus lanatus juice in a dose of 3 ml/kg, Group C was given 6 ml/kg of juice. Two drugs (Diazepam and Fluxetin) were used as standard and given to group D animals. All doses were administered orally. Level of anxiety and depression among animals was tested by light/dark box test and forced swim test. Data was analyzed statistically. Results: Animals treated with Citrullus lanatus juice showed marked reduction in anxiety which was evident from results of light/dark box test while forced swim test revealed no effect on depression. Conclusion: Citrullus lanatus contains important natural anti-oxidants like lycopene and vitamin C which prevent injury to vital organs like liver, heart and brain from toxic effects of reactive oxygen species. Arginine in Citrullus juice is also precursor of neurotransmitters like -Aminobutyric acid (GABA) and glutamate. These results showed that Citrullus because of its components like arginine played an important role in maintaining normal neurological function and ameliorated anxiety and depression. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/257Anti-anxiety effect, Anti-depressant effect, Citrullus lanatus, Diazepam, Fluoxetine |
| spellingShingle | Nuzhat Sultana Shahid Ali Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice Journal of Bahria University Medical and Dental College Anti-anxiety effect, Anti-depressant effect, Citrullus lanatus, Diazepam, Fluoxetine |
| title | Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice |
| title_full | Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice |
| title_fullStr | Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice |
| title_full_unstemmed | Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice |
| title_short | Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice |
| title_sort | evaluation of neurobehavioral effect of citrullus lanatus juice on albino mice |
| topic | Anti-anxiety effect, Anti-depressant effect, Citrullus lanatus, Diazepam, Fluoxetine |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/257 |
| work_keys_str_mv | AT nuzhatsultana evaluationofneurobehavioraleffectofcitrulluslanatusjuiceonalbinomice AT shahidali evaluationofneurobehavioraleffectofcitrulluslanatusjuiceonalbinomice |