Bile micelle binding of structurally diverse ionized drug molecules
Background and purpose: Predicting the food effect on oral drug absorption by physiologically based biopharmaceutical modelling (PBBM) remains challenging. The bile micelle unbound fraction (fu) is one of the primary determinants of the negative food effect for high solubility drugs. To calculate t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2025-07-01
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| Series: | ADMET and DMPK |
| Subjects: | |
| Online Access: | https://pub.iapchem.org/ojs/index.php/admet/article/view/2802 |
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