DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS
This article presents the data on the effect of protargolum solutions in different concentrations on human dermal fibroblasts. For evaluation of the metabolic activity of the cells MTT-test was used. This test is based on the ability of NAD-H-adjective oxydoreductases to represent the amount of viab...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/172 |
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| author | N. V. Mescheryakova E. B. Dashinimaev A. I. Marakhova |
| author_facet | N. V. Mescheryakova E. B. Dashinimaev A. I. Marakhova |
| author_sort | N. V. Mescheryakova |
| collection | DOAJ |
| description | This article presents the data on the effect of protargolum solutions in different concentrations on human dermal fibroblasts. For evaluation of the metabolic activity of the cells MTT-test was used. This test is based on the ability of NAD-H-adjective oxydoreductases to represent the amount of viable cells. It was determined, that the critical concentration of protargolum solution, responsible for inhibitory effect on fibroblasts proliferation is on the range 2 · 10-2 - 5 · 10-1 mg/ml. |
| format | Article |
| id | doaj-art-e5fa3be4be5d41138ce99effc3c10bc1 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-e5fa3be4be5d41138ce99effc3c10bc12025-08-20T02:54:19ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0104180182172DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTSN. V. Mescheryakova0E. B. Dashinimaev1A. I. Marakhova2Peoples' Friendship University of Russia; Pirogov Russian National Research Medical UniversityKoltzov Institute of Developmental Biology, Russian Academy of Sciences; Pirogov Russian National Research Medical UniversityPeoples' Friendship University of RussiaThis article presents the data on the effect of protargolum solutions in different concentrations on human dermal fibroblasts. For evaluation of the metabolic activity of the cells MTT-test was used. This test is based on the ability of NAD-H-adjective oxydoreductases to represent the amount of viable cells. It was determined, that the critical concentration of protargolum solution, responsible for inhibitory effect on fibroblasts proliferation is on the range 2 · 10-2 - 5 · 10-1 mg/ml.https://www.pharmjournal.ru/jour/article/view/172nanoparticlscolloidal silvercytostatic effecthuman dermal fibroblast |
| spellingShingle | N. V. Mescheryakova E. B. Dashinimaev A. I. Marakhova DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS Разработка и регистрация лекарственных средств nanoparticls colloidal silver cytostatic effect human dermal fibroblast |
| title | DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS |
| title_full | DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS |
| title_fullStr | DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS |
| title_full_unstemmed | DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS |
| title_short | DEFINITION OF CYTOSTATIC EFFECT OF PROTARGOLUM SOLUTIONS IN DIFFERENT CONCENTRATIONS ON HUMAN DERMAL FIBROBLASTS |
| title_sort | definition of cytostatic effect of protargolum solutions in different concentrations on human dermal fibroblasts |
| topic | nanoparticls colloidal silver cytostatic effect human dermal fibroblast |
| url | https://www.pharmjournal.ru/jour/article/view/172 |
| work_keys_str_mv | AT nvmescheryakova definitionofcytostaticeffectofprotargolumsolutionsindifferentconcentrationsonhumandermalfibroblasts AT ebdashinimaev definitionofcytostaticeffectofprotargolumsolutionsindifferentconcentrationsonhumandermalfibroblasts AT aimarakhova definitionofcytostaticeffectofprotargolumsolutionsindifferentconcentrationsonhumandermalfibroblasts |