Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film
Purpose. Based on the experiment of the microarteriogenesis that is associated with angiogenesis during tissue repair process in porous silk fibroin films (PSFFs), we investigate the characteristics of micro-arteriogenesis and explore its mechanism. Methods. After the porous silk fibroin materials a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2012/262890 |
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| author | Lun Bai Guangqian Wang Xiaoyan Tan Jianmei Xu |
| author_facet | Lun Bai Guangqian Wang Xiaoyan Tan Jianmei Xu |
| author_sort | Lun Bai |
| collection | DOAJ |
| description | Purpose. Based on the experiment of the microarteriogenesis that is associated with angiogenesis during tissue repair process in porous silk fibroin films (PSFFs), we investigate the characteristics of micro-arteriogenesis and explore its mechanism. Methods. After the porous silk fibroin materials are implanted into the back hypodermal tissue of SD rats, the arteriole development and the morphogenesis of smooth muscle cell are histologically monitored and the micro-arteriogenesis is quantitatively analyzed. Results. 10 days after implantation, the arteriole density reaches the highest level in the junction of silk fibroin materials with tissues. Three weeks later, the arteriolar density in the materials reaches the maximum, and the arterioles in the junction of materials with tissues appear to be in a mature and upgrading state. Modeling of Microarteriogenesis. The arterioles in materials are generated after capillary angiogenesis. It is inferred that arteriolar development does not start until the network of the capillaries is formed. At first, the arterioles grow in the conjunct area of precapillaries with arterioles. Then with the extension of the arterioles, the upgrade of arterioles in connecting area is observed at a later stage. Based on the observation, the conditions and the mechanism of microarterializations as well as the upgrade of arterioles are analyzed. |
| format | Article |
| id | doaj-art-e5f8f2dc45dd415bb35a6395d1c13255 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-e5f8f2dc45dd415bb35a6395d1c132552025-02-03T01:20:33ZengWileyInternational Journal of Biomaterials1687-87871687-87952012-01-01201210.1155/2012/262890262890Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin FilmLun Bai0Guangqian Wang1Xiaoyan Tan2Jianmei Xu3School of Textile and Clothing Engineering, Soochow University, Suzhou 215021, ChinaFaculty of Textile Science and Technology, Shinshu University, Ueda 386-8567, JapanFaculty of Textile Science and Technology, Shinshu University, Ueda 386-8567, JapanFaculty of Textile Science and Technology, Shinshu University, Ueda 386-8567, JapanPurpose. Based on the experiment of the microarteriogenesis that is associated with angiogenesis during tissue repair process in porous silk fibroin films (PSFFs), we investigate the characteristics of micro-arteriogenesis and explore its mechanism. Methods. After the porous silk fibroin materials are implanted into the back hypodermal tissue of SD rats, the arteriole development and the morphogenesis of smooth muscle cell are histologically monitored and the micro-arteriogenesis is quantitatively analyzed. Results. 10 days after implantation, the arteriole density reaches the highest level in the junction of silk fibroin materials with tissues. Three weeks later, the arteriolar density in the materials reaches the maximum, and the arterioles in the junction of materials with tissues appear to be in a mature and upgrading state. Modeling of Microarteriogenesis. The arterioles in materials are generated after capillary angiogenesis. It is inferred that arteriolar development does not start until the network of the capillaries is formed. At first, the arterioles grow in the conjunct area of precapillaries with arterioles. Then with the extension of the arterioles, the upgrade of arterioles in connecting area is observed at a later stage. Based on the observation, the conditions and the mechanism of microarterializations as well as the upgrade of arterioles are analyzed.http://dx.doi.org/10.1155/2012/262890 |
| spellingShingle | Lun Bai Guangqian Wang Xiaoyan Tan Jianmei Xu Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film International Journal of Biomaterials |
| title | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
| title_full | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
| title_fullStr | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
| title_full_unstemmed | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
| title_short | Exploring the Mechanism of Microarteriogenesis in Porous Silk Fibroin Film |
| title_sort | exploring the mechanism of microarteriogenesis in porous silk fibroin film |
| url | http://dx.doi.org/10.1155/2012/262890 |
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