Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy
Yunfeng Wu,1 Yuxi Liu,2 Han Wu,1 Mengying Tong,1 Linyao Du,1 Shuangsong Ren,1 Ying Che1 1Department of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People’s Republic of China; 2Department of Ultrasound, Shandong Second Medical University Affiliated Hospit...
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Dove Medical Press
2025-02-01
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| Series: | International Journal of Nanomedicine |
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| author | Wu Y Liu Y Wu H Tong M Du L Ren S Che Y |
| author_facet | Wu Y Liu Y Wu H Tong M Du L Ren S Che Y |
| author_sort | Wu Y |
| collection | DOAJ |
| description | Yunfeng Wu,1 Yuxi Liu,2 Han Wu,1 Mengying Tong,1 Linyao Du,1 Shuangsong Ren,1 Ying Che1 1Department of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People’s Republic of China; 2Department of Ultrasound, Shandong Second Medical University Affiliated Hospital, Shan Dong, Weifang, People’s Republic of ChinaCorrespondence: Ying Che, Email yche1964@163.comAbstract: Breast cancer is one of the most common types of cancer in women worldwide and is a leading cause of cancer deaths among women. As a result, various treatments have been developed to combat this disease. Breast cancer treatment varies based on its stage and type of pathology. Among the therapeutic options, ultrasound has been employed to assist in the treatment of breast cancer, including radiation therapy, chemotherapy, targeted immunotherapy, hormonal therapy, and, more recently, radiofrequency ablation for early-stage and inoperable patients. One notable advancement is ultrasound-targeted microbubble destruction (UTMD), which is gradually becoming a highly effective and non-invasive anti-tumor modality. This technique can enhance chemical, genetic, immune, and anti-vascular therapies through its physical and biological effects. Specifically, UTMD improves drug transfer efficiency and destroys tumor neovascularization while reducing toxic side effects on the body during tumor treatment. Given these developments, the application of ultrasound-assisted therapy to breast cancer has gained significant attention from research scholars. In this review, we will discuss the development of various therapeutic modalities for breast cancer and, importantly, highlight the application of ultrasound microbubble-targeted disruption techniques in breast cancer treatment.Keywords: ultrasound-targeted microbubble destruction, breast cancer, microbubble, chemotherapy, TME, radiofrequency ablation |
| format | Article |
| id | doaj-art-e5f60056b7bf4e589c83f77ed1d74943 |
| institution | Kabale University |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-e5f60056b7bf4e589c83f77ed1d749432025-02-04T17:15:41ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-02-01Volume 201425144299835Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer TherapyWu YLiu YWu HTong MDu LRen SChe YYunfeng Wu,1 Yuxi Liu,2 Han Wu,1 Mengying Tong,1 Linyao Du,1 Shuangsong Ren,1 Ying Che1 1Department of Ultrasound, The First Affiliated Hospital of Dalian Medical University, Liaoning, Dalian, People’s Republic of China; 2Department of Ultrasound, Shandong Second Medical University Affiliated Hospital, Shan Dong, Weifang, People’s Republic of ChinaCorrespondence: Ying Che, Email yche1964@163.comAbstract: Breast cancer is one of the most common types of cancer in women worldwide and is a leading cause of cancer deaths among women. As a result, various treatments have been developed to combat this disease. Breast cancer treatment varies based on its stage and type of pathology. Among the therapeutic options, ultrasound has been employed to assist in the treatment of breast cancer, including radiation therapy, chemotherapy, targeted immunotherapy, hormonal therapy, and, more recently, radiofrequency ablation for early-stage and inoperable patients. One notable advancement is ultrasound-targeted microbubble destruction (UTMD), which is gradually becoming a highly effective and non-invasive anti-tumor modality. This technique can enhance chemical, genetic, immune, and anti-vascular therapies through its physical and biological effects. Specifically, UTMD improves drug transfer efficiency and destroys tumor neovascularization while reducing toxic side effects on the body during tumor treatment. Given these developments, the application of ultrasound-assisted therapy to breast cancer has gained significant attention from research scholars. In this review, we will discuss the development of various therapeutic modalities for breast cancer and, importantly, highlight the application of ultrasound microbubble-targeted disruption techniques in breast cancer treatment.Keywords: ultrasound-targeted microbubble destruction, breast cancer, microbubble, chemotherapy, TME, radiofrequency ablationhttps://www.dovepress.com/advances-in-ultrasound-targeted-microbubble-destruction-utmd-for-breas-peer-reviewed-fulltext-article-IJNultrasound-targeted microbubble destructionbreast cancermicrobubblechemotherapytmeradiofrequency ablation |
| spellingShingle | Wu Y Liu Y Wu H Tong M Du L Ren S Che Y Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy International Journal of Nanomedicine ultrasound-targeted microbubble destruction breast cancer microbubble chemotherapy tme radiofrequency ablation |
| title | Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy |
| title_full | Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy |
| title_fullStr | Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy |
| title_full_unstemmed | Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy |
| title_short | Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy |
| title_sort | advances in ultrasound targeted microbubble destruction utmd for breast cancer therapy |
| topic | ultrasound-targeted microbubble destruction breast cancer microbubble chemotherapy tme radiofrequency ablation |
| url | https://www.dovepress.com/advances-in-ultrasound-targeted-microbubble-destruction-utmd-for-breas-peer-reviewed-fulltext-article-IJN |
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