Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection.
Following Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular in the liver, during the acute stage of disease. While excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-05-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004097&type=printable |
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| author | Xiaojun Chen Xiaowei Yang Yong Li Jifeng Zhu Sha Zhou Zhipeng Xu Lei He Xue Xue Weiwei Zhang Xiaoxiao Dong Henry Wu Carrie J Li Hsiang-Ting Hsu Wenjun Kong Feng Liu Prem B Tripathi Michelle S Yu Jason Chang Liang Zhou Chuan Su |
| author_facet | Xiaojun Chen Xiaowei Yang Yong Li Jifeng Zhu Sha Zhou Zhipeng Xu Lei He Xue Xue Weiwei Zhang Xiaoxiao Dong Henry Wu Carrie J Li Hsiang-Ting Hsu Wenjun Kong Feng Liu Prem B Tripathi Michelle S Yu Jason Chang Liang Zhou Chuan Su |
| author_sort | Xiaojun Chen |
| collection | DOAJ |
| description | Following Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular in the liver, during the acute stage of disease. While excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment in chronically infected host. However, the exact mechanism of hepatic granuloma formation has remained obscure. In this study, we for the first time showed that follicular helper T (Tfh) cells are recruited to the liver to upregulate hepatic granuloma formation and liver injury in S. japonicum-infected mice, and identified a novel function of macrophages in Tfh cell induction. In addition, our results showed that the generation of Tfh cells driven by macrophages is dependent on cell-cell contact and the level of inducible costimulator ligand (ICOSL) on macrophages which is regulated by CD40-CD40L signaling. Our findings uncovered a previously unappreciated role for Tfh cells in liver pathology caused by S. japonicum infection in mice. |
| format | Article |
| id | doaj-art-e5ef30c5e4bc4bd4bc19f75733fdb60d |
| institution | OA Journals |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2014-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-e5ef30c5e4bc4bd4bc19f75733fdb60d2025-08-20T02:14:43ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742014-05-01105e100409710.1371/journal.ppat.1004097Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection.Xiaojun ChenXiaowei YangYong LiJifeng ZhuSha ZhouZhipeng XuLei HeXue XueWeiwei ZhangXiaoxiao DongHenry WuCarrie J LiHsiang-Ting HsuWenjun KongFeng LiuPrem B TripathiMichelle S YuJason ChangLiang ZhouChuan SuFollowing Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular in the liver, during the acute stage of disease. While excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment in chronically infected host. However, the exact mechanism of hepatic granuloma formation has remained obscure. In this study, we for the first time showed that follicular helper T (Tfh) cells are recruited to the liver to upregulate hepatic granuloma formation and liver injury in S. japonicum-infected mice, and identified a novel function of macrophages in Tfh cell induction. In addition, our results showed that the generation of Tfh cells driven by macrophages is dependent on cell-cell contact and the level of inducible costimulator ligand (ICOSL) on macrophages which is regulated by CD40-CD40L signaling. Our findings uncovered a previously unappreciated role for Tfh cells in liver pathology caused by S. japonicum infection in mice.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004097&type=printable |
| spellingShingle | Xiaojun Chen Xiaowei Yang Yong Li Jifeng Zhu Sha Zhou Zhipeng Xu Lei He Xue Xue Weiwei Zhang Xiaoxiao Dong Henry Wu Carrie J Li Hsiang-Ting Hsu Wenjun Kong Feng Liu Prem B Tripathi Michelle S Yu Jason Chang Liang Zhou Chuan Su Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. PLoS Pathogens |
| title | Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. |
| title_full | Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. |
| title_fullStr | Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. |
| title_full_unstemmed | Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. |
| title_short | Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection. |
| title_sort | follicular helper t cells promote liver pathology in mice during schistosoma japonicum infection |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004097&type=printable |
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