Identifying the epileptic network by linking interictal functional and structural connectivity
Abstract Over the last two decades, it has become increasingly clear that epilepsy is a network disorder. However, it is unclear whether these networks are established only during seizures or persist interictally. The goal of this study was to identify whether functional seizure networks exist inter...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-93978-3 |
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| author | Ujwal Boddeti Pue Farooque Hari McGrath Jennifer Percy Omar Chishti Robert B. Duckrow Dennis Spencer Hitten P. Zaveri Alexander Ksendzovsky |
| author_facet | Ujwal Boddeti Pue Farooque Hari McGrath Jennifer Percy Omar Chishti Robert B. Duckrow Dennis Spencer Hitten P. Zaveri Alexander Ksendzovsky |
| author_sort | Ujwal Boddeti |
| collection | DOAJ |
| description | Abstract Over the last two decades, it has become increasingly clear that epilepsy is a network disorder. However, it is unclear whether these networks are established only during seizures or persist interictally. The goal of this study was to identify whether functional seizure networks exist interictally and evaluate if there is a structural basis to these networks. We identified four patients with mesial temporal lobe epilepsy who underwent resective epilepsy surgery. We estimated functional and structural connectivity across intracranial electrode contacts involved in seizure onset, early spread, and uninvolved controls. Across all interictal epochs considered, we found higher functional and white matter connectivity across cortical regions involved in seizure spread. Additionally, we observed that the patient in our cohort with the best seizure outcome had the highest functional connectivity across seizure contacts. Functional connectivity findings suggest the presence of an interictal seizure network that parallels underlying structural connectivity. Furthermore, our findings suggest that disruption or ablation of highly connected seizure regions may be necessary to achieve improved post-operative seizure freedom. |
| format | Article |
| id | doaj-art-e5eafb696b034efd8029096ecd955e19 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e5eafb696b034efd8029096ecd955e192025-08-20T03:41:41ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-93978-3Identifying the epileptic network by linking interictal functional and structural connectivityUjwal Boddeti0Pue Farooque1Hari McGrath2Jennifer Percy3Omar Chishti4Robert B. Duckrow5Dennis Spencer6Hitten P. Zaveri7Alexander Ksendzovsky8Surgical Neurology Branch, NINDS, National Institutes of HealthDepartment of Neurosurgery, Yale UniversityDepartment of Neurosurgery, Yale UniversityDepartment of Neurosurgery, Yale UniversityDepartment of Neurosurgery, Yale UniversityDepartment of Neurosurgery, Yale UniversityDepartment of Neurosurgery, Yale UniversityDepartment of Neurology, Yale UniversityDepartment of Neurosurgery, University of Maryland School of MedicineAbstract Over the last two decades, it has become increasingly clear that epilepsy is a network disorder. However, it is unclear whether these networks are established only during seizures or persist interictally. The goal of this study was to identify whether functional seizure networks exist interictally and evaluate if there is a structural basis to these networks. We identified four patients with mesial temporal lobe epilepsy who underwent resective epilepsy surgery. We estimated functional and structural connectivity across intracranial electrode contacts involved in seizure onset, early spread, and uninvolved controls. Across all interictal epochs considered, we found higher functional and white matter connectivity across cortical regions involved in seizure spread. Additionally, we observed that the patient in our cohort with the best seizure outcome had the highest functional connectivity across seizure contacts. Functional connectivity findings suggest the presence of an interictal seizure network that parallels underlying structural connectivity. Furthermore, our findings suggest that disruption or ablation of highly connected seizure regions may be necessary to achieve improved post-operative seizure freedom.https://doi.org/10.1038/s41598-025-93978-3Diffusion tensor imagingEpilepsyFunctional connectivityInterictal connectivityMesial temporal lobe epilepsySeizure networks |
| spellingShingle | Ujwal Boddeti Pue Farooque Hari McGrath Jennifer Percy Omar Chishti Robert B. Duckrow Dennis Spencer Hitten P. Zaveri Alexander Ksendzovsky Identifying the epileptic network by linking interictal functional and structural connectivity Scientific Reports Diffusion tensor imaging Epilepsy Functional connectivity Interictal connectivity Mesial temporal lobe epilepsy Seizure networks |
| title | Identifying the epileptic network by linking interictal functional and structural connectivity |
| title_full | Identifying the epileptic network by linking interictal functional and structural connectivity |
| title_fullStr | Identifying the epileptic network by linking interictal functional and structural connectivity |
| title_full_unstemmed | Identifying the epileptic network by linking interictal functional and structural connectivity |
| title_short | Identifying the epileptic network by linking interictal functional and structural connectivity |
| title_sort | identifying the epileptic network by linking interictal functional and structural connectivity |
| topic | Diffusion tensor imaging Epilepsy Functional connectivity Interictal connectivity Mesial temporal lobe epilepsy Seizure networks |
| url | https://doi.org/10.1038/s41598-025-93978-3 |
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