Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts

Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts

Leptin, a hormone secreted by adipose tissue, plays a pivotal role in maintaining energy metabolism and bone quality. Dysregulation of leptin can lead to the development of various pathological conditions. For example, the concentration of leptin is increased in individuals with obesity, and this in...

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Bibliographic Details
Main Authors: Chien-Ning Hsu, Chih-Hong Kao, Chin-Hua Yang, Ming-Te Cheng, Yu-Pao Hsu, Shinn-Gwo Hong, Chao-Ling Yao, Yu-Hsu Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Journal of Physiological Investigation
Subjects:
bone remodeling
leptin
osteoblast
osteoclast
pro-inflammatory genes
Online Access:https://journals.lww.com/cjop/fulltext/2024/67060/leptin_promotes_the_expression_of_pro_inflammatory.7.aspx
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