Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes
Silicosis is an occupational fibrotic lung disease caused by exposure to respirable crystalline silica dust particles produced during industrial activities. Other crystalline silica-induced pulmonary disorders include a predisposition to mycobacterial infections, obstructive airway diseases, idiopat...
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Elsevier
2025-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000599 |
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| author | Prasad Sherekar Sanvidhan G. Suke Archana Dhok Srikant Malegaonkar Shrikrishna A. Dhale |
| author_facet | Prasad Sherekar Sanvidhan G. Suke Archana Dhok Srikant Malegaonkar Shrikrishna A. Dhale |
| author_sort | Prasad Sherekar |
| collection | DOAJ |
| description | Silicosis is an occupational fibrotic lung disease caused by exposure to respirable crystalline silica dust particles produced during industrial activities. Other crystalline silica-induced pulmonary disorders include a predisposition to mycobacterial infections, obstructive airway diseases, idiopathic pulmonary fibrosis, and lung cancer. This review paper discusses the burden of silicosis and associated co-morbidities in developed as well as developing countries globally using the published data of various government agencies, related organizations, and epidemiological findings. Moreover, it sheds light on diverse mechanisms of silicosis, outlining molecular events and peculiar alterations in lung parenchyma leading to this occupational lung disease. Evaluation of pathophysiological mechanisms could aid in the identification of novel target molecules and treatments; to date, there is no curative treatment for silicosis. In recent periods, a lot of attention has been focused on the development and fabrication of suitable nanocarriers for improved and sustained drug delivery in the pulmonary system. Nanoparticle-based therapeutic modality has been evaluated in in-vitro and ex-vivo silicosis models for prolongation of drug activity and improved therapeutic outcomes. The preclinical findings open the doors to clinical trials for operational and regenerative nanoformulations, which eventually create a positive change in medical practice. The following review summarizes various therapeutic approaches available and in the pipe line for silicosis and also stresses the preventive practices for effectively combating this occupational hazard. |
| format | Article |
| id | doaj-art-e5e2b7a0d8f14316987b39444d3a0830 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-e5e2b7a0d8f14316987b39444d3a08302025-02-05T04:32:08ZengElsevierToxicology Reports2214-75002025-06-0114101941Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimesPrasad Sherekar0Sanvidhan G. Suke1Archana Dhok2Srikant Malegaonkar3Shrikrishna A. Dhale4Department of Biotechnology, Priyadarshini College of Engineering, Priyadarshini Campus, Hingna Road, Nagpur 440 019, India; Department of Biochemistry, Jawaharlal Nehru Medical College, DattaMeghe Institute of Higher Education and Research (Deemed to be University), Wardha 442 005, IndiaDepartment of Biotechnology, Priyadarshini College of Engineering, Priyadarshini Campus, Hingna Road, Nagpur 440 019, India; Corresponding author.Department of Biochemistry, Jawaharlal Nehru Medical College, DattaMeghe Institute of Higher Education and Research (Deemed to be University), Wardha 442 005, IndiaDepartment of Pulmonary Medicine, All India Institute of Medical Sciences, MIHAN, Nagpur 441 108, IndiaDepartment of Civil Engineering, Priyadarshini College of Engineering, Priyadarshini Campus, Hingna Road, Nagpur 440 019, IndiaSilicosis is an occupational fibrotic lung disease caused by exposure to respirable crystalline silica dust particles produced during industrial activities. Other crystalline silica-induced pulmonary disorders include a predisposition to mycobacterial infections, obstructive airway diseases, idiopathic pulmonary fibrosis, and lung cancer. This review paper discusses the burden of silicosis and associated co-morbidities in developed as well as developing countries globally using the published data of various government agencies, related organizations, and epidemiological findings. Moreover, it sheds light on diverse mechanisms of silicosis, outlining molecular events and peculiar alterations in lung parenchyma leading to this occupational lung disease. Evaluation of pathophysiological mechanisms could aid in the identification of novel target molecules and treatments; to date, there is no curative treatment for silicosis. In recent periods, a lot of attention has been focused on the development and fabrication of suitable nanocarriers for improved and sustained drug delivery in the pulmonary system. Nanoparticle-based therapeutic modality has been evaluated in in-vitro and ex-vivo silicosis models for prolongation of drug activity and improved therapeutic outcomes. The preclinical findings open the doors to clinical trials for operational and regenerative nanoformulations, which eventually create a positive change in medical practice. The following review summarizes various therapeutic approaches available and in the pipe line for silicosis and also stresses the preventive practices for effectively combating this occupational hazard.http://www.sciencedirect.com/science/article/pii/S2214750025000599Fibrotic lung diseasesMolecular mechanismNanotherapeuticsOccupational healthSilica dust toxicitySilicosis |
| spellingShingle | Prasad Sherekar Sanvidhan G. Suke Archana Dhok Srikant Malegaonkar Shrikrishna A. Dhale Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes Toxicology Reports Fibrotic lung diseases Molecular mechanism Nanotherapeutics Occupational health Silica dust toxicity Silicosis |
| title | Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes |
| title_full | Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes |
| title_fullStr | Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes |
| title_full_unstemmed | Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes |
| title_short | Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes |
| title_sort | global scenario of silica associated diseases a review on emerging pathophysiology of silicosis and potential therapeutic regimes |
| topic | Fibrotic lung diseases Molecular mechanism Nanotherapeutics Occupational health Silica dust toxicity Silicosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000599 |
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