Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial
Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual p...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/685281 |
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| _version_ | 1832555399586250752 |
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| author | Kathryn S. Merriam Kristina A. Leake Mollie Elliot Michelle L. Matthews Rebecca S. Usadi Bradley S. Hurst |
| author_facet | Kathryn S. Merriam Kristina A. Leake Mollie Elliot Michelle L. Matthews Rebecca S. Usadi Bradley S. Hurst |
| author_sort | Kathryn S. Merriam |
| collection | DOAJ |
| description | Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum progesterone for both male and female partners were measured 10 hours after intercourse. One week later, subjects were crossed over to receive the opposite formulation. In the third week, women used progesterone gel at night and abstained from intercourse. Results. Serum progesterone was significantly reduced with vaginal progesterone gel + intercourse compared with vaginal progesterone gel + abstinence (P=0.0075). Men absorbed significant progesterone during intercourse with a female partner using vaginal progesterone gel compared to placebo (P=0.0008). Conclusion(s). Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support. Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido. This study is registered under Clinical Trial number NCT01959464. |
| format | Article |
| id | doaj-art-e5d4b44e7d0f447795a72d2c3773767e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e5d4b44e7d0f447795a72d2c3773767e2025-02-03T05:48:24ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/685281685281Sexual Absorption of Vaginal Progesterone: A Randomized Control TrialKathryn S. Merriam0Kristina A. Leake1Mollie Elliot2Michelle L. Matthews3Rebecca S. Usadi4Bradley S. Hurst5Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USAObjective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum progesterone for both male and female partners were measured 10 hours after intercourse. One week later, subjects were crossed over to receive the opposite formulation. In the third week, women used progesterone gel at night and abstained from intercourse. Results. Serum progesterone was significantly reduced with vaginal progesterone gel + intercourse compared with vaginal progesterone gel + abstinence (P=0.0075). Men absorbed significant progesterone during intercourse with a female partner using vaginal progesterone gel compared to placebo (P=0.0008). Conclusion(s). Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support. Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido. This study is registered under Clinical Trial number NCT01959464.http://dx.doi.org/10.1155/2015/685281 |
| spellingShingle | Kathryn S. Merriam Kristina A. Leake Mollie Elliot Michelle L. Matthews Rebecca S. Usadi Bradley S. Hurst Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial International Journal of Endocrinology |
| title | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
| title_full | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
| title_fullStr | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
| title_full_unstemmed | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
| title_short | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
| title_sort | sexual absorption of vaginal progesterone a randomized control trial |
| url | http://dx.doi.org/10.1155/2015/685281 |
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