Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews
ABSTRACT Objectives To assess and synthesize the effect size and quality of the literature on the placebo and nocebo effects on motor performance and motor‐related perceptive responses. Design Umbrella review. Data sources Medline, Embase, Lilacs, Cochrane Database of Systematic Reviews for peer‐rev...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70534 |
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| author | Cayque Brietzke Wesley Alves Ribeiro Paulo Estevão Franco‐Alvarenga Raul Canestri Ìtalo Vínicius Gustavo Vasconcelos Julio Cesario Nelson Carvas Junior Vitor de Salles Painelli Flávio Oliveira Pires |
| author_facet | Cayque Brietzke Wesley Alves Ribeiro Paulo Estevão Franco‐Alvarenga Raul Canestri Ìtalo Vínicius Gustavo Vasconcelos Julio Cesario Nelson Carvas Junior Vitor de Salles Painelli Flávio Oliveira Pires |
| author_sort | Cayque Brietzke |
| collection | DOAJ |
| description | ABSTRACT Objectives To assess and synthesize the effect size and quality of the literature on the placebo and nocebo effects on motor performance and motor‐related perceptive responses. Design Umbrella review. Data sources Medline, Embase, Lilacs, Cochrane Database of Systematic Reviews for peer‐reviewed literature, PROSPERO for protocols, and the Open Access Theses and Dissertations for gray literature. Eligibility criteria for selecting studies Population—human participants with varied health conditions; intervention: placebo; control: no treatment or active intervention; outcome: motor performance (primary) and perceptual variables (secondary); study design—ystematic reviews with or without meta‐analysis. Results In total, 3432 records were gathered from searches, resulting in 13 eligible reviews after screening. These reviews encompassed 247 original studies, with 221 focusing on the placebo effect and 26 on the nocebo effect. Among all eligible systematic reviews, five conducted meta‐analysis with 5036 participants, and one provided a summary of effect sizes reported by the original studies with 1215 participants. The reviews reported small to large effects of placebo (SMD = 0.09–0.93) and nocebo (SMD = 0.37–1.20), and only two conducted the GRADE assessment. Conclusion We found varied placebo and nocebo effects on motor performance, likely due to the poor quality of the methodology used by most reviews, highlighting the need for well‐conducted systematic reviews on the placebo and nocebo phenomena. |
| format | Article |
| id | doaj-art-e5cf8519e68b4de6ad8a6f2630c27baa |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-e5cf8519e68b4de6ad8a6f2630c27baa2025-08-20T03:02:45ZengWileyBrain and Behavior2162-32792025-06-01156n/an/a10.1002/brb3.70534Placebo and Nocebo Effects in Motor Performance: An Overview of ReviewsCayque Brietzke0Wesley Alves Ribeiro1Paulo Estevão Franco‐Alvarenga2Raul Canestri3Ìtalo Vínicius4Gustavo Vasconcelos5Julio Cesario6Nelson Carvas Junior7Vitor de Salles Painelli8Flávio Oliveira Pires9Exercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilPaulista UniversityExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilExercise Psychophysiology Research Group. School of Arts Sciences and Humanities–University of São Paulo São Paulo BrazilABSTRACT Objectives To assess and synthesize the effect size and quality of the literature on the placebo and nocebo effects on motor performance and motor‐related perceptive responses. Design Umbrella review. Data sources Medline, Embase, Lilacs, Cochrane Database of Systematic Reviews for peer‐reviewed literature, PROSPERO for protocols, and the Open Access Theses and Dissertations for gray literature. Eligibility criteria for selecting studies Population—human participants with varied health conditions; intervention: placebo; control: no treatment or active intervention; outcome: motor performance (primary) and perceptual variables (secondary); study design—ystematic reviews with or without meta‐analysis. Results In total, 3432 records were gathered from searches, resulting in 13 eligible reviews after screening. These reviews encompassed 247 original studies, with 221 focusing on the placebo effect and 26 on the nocebo effect. Among all eligible systematic reviews, five conducted meta‐analysis with 5036 participants, and one provided a summary of effect sizes reported by the original studies with 1215 participants. The reviews reported small to large effects of placebo (SMD = 0.09–0.93) and nocebo (SMD = 0.37–1.20), and only two conducted the GRADE assessment. Conclusion We found varied placebo and nocebo effects on motor performance, likely due to the poor quality of the methodology used by most reviews, highlighting the need for well‐conducted systematic reviews on the placebo and nocebo phenomena.https://doi.org/10.1002/brb3.70534adverse effectsmeta‐analysisnoceboplacebopsychomotor performanceresearch synthesis |
| spellingShingle | Cayque Brietzke Wesley Alves Ribeiro Paulo Estevão Franco‐Alvarenga Raul Canestri Ìtalo Vínicius Gustavo Vasconcelos Julio Cesario Nelson Carvas Junior Vitor de Salles Painelli Flávio Oliveira Pires Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews Brain and Behavior adverse effects meta‐analysis nocebo placebo psychomotor performance research synthesis |
| title | Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews |
| title_full | Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews |
| title_fullStr | Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews |
| title_full_unstemmed | Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews |
| title_short | Placebo and Nocebo Effects in Motor Performance: An Overview of Reviews |
| title_sort | placebo and nocebo effects in motor performance an overview of reviews |
| topic | adverse effects meta‐analysis nocebo placebo psychomotor performance research synthesis |
| url | https://doi.org/10.1002/brb3.70534 |
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