LINC02167 stabilizes KSR1 mRNA in an m5C-dependent manner to regulate the ERK/MAPK signaling pathway and promotes colorectal cancer metastasis

LINC02167 stabilizes KSR1 mRNA in an m5C-dependent manner to regulate the ERK/MAPK signaling pathway and promotes colorectal cancer metastasis

Abstract Background Metastasis is a leading cause of colorectal cancer (CRC)-related mortality, yet its molecular mechanisms remain poorly understood. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of CRC metastasis, but their specific roles are not fully elucidated. This study id...

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Bibliographic Details
Main Authors: Junwen Qi, Tao Jiang, Bowen Liu, Qihang Hu, Junnan Chen, Ning Ma, Yixin Xu, Hu Song, Jun Song
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Long noncoding RNA
Metastasis
KSR1
5-methylcytosine
Transcription
Online Access:https://doi.org/10.1186/s13046-025-03368-w
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