Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood.
<h4>Objective</h4>Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during ch...
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| Format: | Article |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041575&type=printable |
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| author | Anna-Maija Tolppanen Adrian Sayers William D Fraser Glyn Lewis Stanley Zammit John McGrath Debbie A Lawlor |
| author_facet | Anna-Maija Tolppanen Adrian Sayers William D Fraser Glyn Lewis Stanley Zammit John McGrath Debbie A Lawlor |
| author_sort | Anna-Maija Tolppanen |
| collection | DOAJ |
| description | <h4>Objective</h4>Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D(3) and 25(OH)D(2), have similar associations with psychosis-related outcomes.<h4>Methods</h4>We investigated the association between serum 25(OH)D(3) and 25(OH)D(2) concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D(3) and 25(OH)D(2) concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).<h4>Results</h4>Higher 25(OH)D(3) concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D(2) were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D(2) concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.<h4>Conclusions</h4>Our findings of an inverse association of 25(OH)D(3) with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes. |
| format | Article |
| id | doaj-art-e5bfaa52d6dd4a71a4a2c8741c1f594d |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e5bfaa52d6dd4a71a4a2c8741c1f594d2025-08-20T03:09:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4157510.1371/journal.pone.0041575Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood.Anna-Maija TolppanenAdrian SayersWilliam D FraserGlyn LewisStanley ZammitJohn McGrathDebbie A Lawlor<h4>Objective</h4>Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D(3) and 25(OH)D(2), have similar associations with psychosis-related outcomes.<h4>Methods</h4>We investigated the association between serum 25(OH)D(3) and 25(OH)D(2) concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D(3) and 25(OH)D(2) concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).<h4>Results</h4>Higher 25(OH)D(3) concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D(2) were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D(2) concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.<h4>Conclusions</h4>Our findings of an inverse association of 25(OH)D(3) with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041575&type=printable |
| spellingShingle | Anna-Maija Tolppanen Adrian Sayers William D Fraser Glyn Lewis Stanley Zammit John McGrath Debbie A Lawlor Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. PLoS ONE |
| title | Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. |
| title_full | Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. |
| title_fullStr | Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. |
| title_full_unstemmed | Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. |
| title_short | Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood. |
| title_sort | serum 25 hydroxyvitamin d3 and d2 and non clinical psychotic experiences in childhood |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041575&type=printable |
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