Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal

Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal

Abstract Background Stem cell therapies may potentially be used in regenerative and reconstructive medicine due to their ability for self-renewal and differentiation. Stressful conditions, such as hyperglycemia, adversely affect stem cell functions, impairing their function and promoting differentia...

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Main Authors: Ayaz Ali, Wei-Wen Kuo, Chia-Hua Kuo, Jeng-Feng Lo, Dennis Jine-Yuan Hsieh, Peiying Pai, Tsung-Jung Ho, Marthandam Asokan Shibu, Shinn-Zong Lin, Chih-Yang Huang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Biological Research
Subjects:
Carboxyl terminus of HSP70 interacting protein
p53
Hyperglycemia
Self-renewal
Mesenchymal stem cells
Online Access:https://doi.org/10.1186/s40659-025-00604-7
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