The blues and rhythm
Most organisms, including humans, show daily rhythms in many aspects of physiology and behavior, and abnormalities in the rhythms are potential risk factors for various diseases. Mood disorders such as depression are no exception. Accumulating evidence suggests strong associations between circadian...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010223001992 |
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| _version_ | 1832087852343623680 |
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| author | Kiyomichi Imamura Ayaka Bota Toshihiko Shirafuji Toru Takumi |
| author_facet | Kiyomichi Imamura Ayaka Bota Toshihiko Shirafuji Toru Takumi |
| author_sort | Kiyomichi Imamura |
| collection | DOAJ |
| description | Most organisms, including humans, show daily rhythms in many aspects of physiology and behavior, and abnormalities in the rhythms are potential risk factors for various diseases. Mood disorders such as depression are no exception. Accumulating evidence suggests strong associations between circadian disturbances and the development of depression. Numerous studies have shown that interventions to circadian rhythms trigger depression-like phenotypes in human cases and animal models. Conversely, mood changes can affect circadian rhythms as symptoms of depression. Our preliminary data suggest that the phosphorylation signal pathway of the clock protein may act as a common pathway for mood and clock regulation. We hypothesize that mood regulation and circadian rhythms may influence each other and may share a common regulatory mechanism. This review provides an overview of circadian disturbances in animal models and human patients with depression. |
| format | Article |
| id | doaj-art-e5b5bc8fbb1246feb901d9fcfca01eb0 |
| institution | Kabale University |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-e5b5bc8fbb1246feb901d9fcfca01eb02025-02-06T05:11:00ZengElsevierNeuroscience Research0168-01022025-02-012114956The blues and rhythmKiyomichi Imamura0Ayaka Bota1Toshihiko Shirafuji2Toru Takumi3Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, JapanDepartment of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, JapanDepartment of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, JapanDepartment of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, Japan; RIKEN Center for Biosystems Dynamics Research, Chuo, Kobe 650-0047, Japan; Corresponding author at: Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe 650-0017, Japan.Most organisms, including humans, show daily rhythms in many aspects of physiology and behavior, and abnormalities in the rhythms are potential risk factors for various diseases. Mood disorders such as depression are no exception. Accumulating evidence suggests strong associations between circadian disturbances and the development of depression. Numerous studies have shown that interventions to circadian rhythms trigger depression-like phenotypes in human cases and animal models. Conversely, mood changes can affect circadian rhythms as symptoms of depression. Our preliminary data suggest that the phosphorylation signal pathway of the clock protein may act as a common pathway for mood and clock regulation. We hypothesize that mood regulation and circadian rhythms may influence each other and may share a common regulatory mechanism. This review provides an overview of circadian disturbances in animal models and human patients with depression.http://www.sciencedirect.com/science/article/pii/S0168010223001992CircadianMood disorderDepressionSleep disorderClock gene |
| spellingShingle | Kiyomichi Imamura Ayaka Bota Toshihiko Shirafuji Toru Takumi The blues and rhythm Neuroscience Research Circadian Mood disorder Depression Sleep disorder Clock gene |
| title | The blues and rhythm |
| title_full | The blues and rhythm |
| title_fullStr | The blues and rhythm |
| title_full_unstemmed | The blues and rhythm |
| title_short | The blues and rhythm |
| title_sort | blues and rhythm |
| topic | Circadian Mood disorder Depression Sleep disorder Clock gene |
| url | http://www.sciencedirect.com/science/article/pii/S0168010223001992 |
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