iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau

iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau

Frontotemporal Lobar Degeneration (FTLD) is a neurodegenerative disorder that affects the frontal and temporal lobes, which are crucial for regulating personality, behavior, and language. Pathologically, FTLD is characterized by Tau protein accumulation and neuronal death. In our effort to identify...

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Bibliographic Details
Main Authors: Keiko Imamura, Ayako Nagahashi, Aya Okusa, Tomoki Sakasai, Kayoko Tsukita, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Naruhiko Sahara, Nicholas M. Kanaan, Makoto Higuchi, Kohji Mori, Manabu Ikeda, Haruhisa Inoue
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:European Journal of Cell Biology
Subjects:
Tau
FTLD
excitability
gabapentinoids
iPSCs
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000093
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