Second generation CD2-targeting LFA-3 fusion protein SBT115301 to restore immune homeostasis in autoimmune disease

Second generation CD2-targeting LFA-3 fusion protein SBT115301 to restore immune homeostasis in autoimmune disease

Summary: In autoimmunity, an imbalance of effector (Teff) and regulatory (Treg)T cells contributes to inflammation and tissue destruction. CD2, highly expressed on Teff and at lower levels on Treg and naive T cells (Tn), is an attractive target for depleting Teff at sites of inflammation. SBT115301...

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Bibliographic Details
Main Authors: Herve Lebrec, John Bui, Jonathan M. Clingan, Jason Do, Jason Dubovsky, Leonard Dragone, Ekaterina Gibiansky, Wing Yu Lam, Katherine Matsuda, Lauren Mihalcik, Frederick Ramsdell, Anne-Renee van der Vuurst de Vries, Yuanyuan Xiao, Jeffrey A. Bluestone
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Health sciences
Immunology
Medical specialty
Medicine
Pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007084
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