Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature
Calciphylaxis, or calcific uremic arteriolopathy, commonly affects people with end-stage renal disease and carries with it a high rate of morbidity and mortality. Here, we present the unusual case of a 56-year-old woman, with extensive medical problems, who developed calciphylaxis in the presence of...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/823210 |
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| author | Jennifer Bishop Eric Brown Augusto Podesta Cathrine Troy Xiang (Eric) Dong |
| author_facet | Jennifer Bishop Eric Brown Augusto Podesta Cathrine Troy Xiang (Eric) Dong |
| author_sort | Jennifer Bishop |
| collection | DOAJ |
| description | Calciphylaxis, or calcific uremic arteriolopathy, commonly affects people with end-stage renal disease and carries with it a high rate of morbidity and mortality. Here, we present the unusual case of a 56-year-old woman, with extensive medical problems, who developed calciphylaxis in the presence of primary hyperparathyroidism. Our patient initially presented with bilateral, exquisitely tender thigh lesions. The diagnosis of calciphylaxis was rendered histologically by extensive calcification of the subcutaneous blood vessels. Subsequent parathyroidectomy identified the presence of a hyperactive mediastinal parathyroid adenoma, weighing 0.62 grams. Postoperatively, the patient had normalization of hypercalcemia and parathyroid hormone levels, with subsequent healing of her thigh wounds. Currently, there have been sixteen cases described in the English literature, with only nine being offered a potentially therapeutic parathyroidectomy. It is contingent upon the vigilant physician to diagnose and properly manage this difficult yet treatable condition. |
| format | Article |
| id | doaj-art-e5ab4286bb664378a1c523790a1ad340 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e5ab4286bb664378a1c523790a1ad3402025-02-03T01:01:39ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/823210823210Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the LiteratureJennifer Bishop0Eric Brown1Augusto Podesta2Cathrine Troy3Xiang (Eric) Dong4Department of Surgery, Stamford Hospital Columbia University, 30 Shelburne Road, Stamford, CT 06904, USADepartment of Nephrology, Stamford Hospital Columbia University, 30 Shelburne Road, Stamford, CT 06904, USADepartment of Pathology, Stamford Hospital Columbia University, 30 Shelburne Road, Stamford, CT 06904, USADepartment of Internal Medicine, Stamford Hospital Columbia University, 30 Shelburne Road, Stamford, CT 06904, USADepartment of Surgery, Stamford Hospital Columbia University, 30 Shelburne Road, Stamford, CT 06904, USACalciphylaxis, or calcific uremic arteriolopathy, commonly affects people with end-stage renal disease and carries with it a high rate of morbidity and mortality. Here, we present the unusual case of a 56-year-old woman, with extensive medical problems, who developed calciphylaxis in the presence of primary hyperparathyroidism. Our patient initially presented with bilateral, exquisitely tender thigh lesions. The diagnosis of calciphylaxis was rendered histologically by extensive calcification of the subcutaneous blood vessels. Subsequent parathyroidectomy identified the presence of a hyperactive mediastinal parathyroid adenoma, weighing 0.62 grams. Postoperatively, the patient had normalization of hypercalcemia and parathyroid hormone levels, with subsequent healing of her thigh wounds. Currently, there have been sixteen cases described in the English literature, with only nine being offered a potentially therapeutic parathyroidectomy. It is contingent upon the vigilant physician to diagnose and properly manage this difficult yet treatable condition.http://dx.doi.org/10.1155/2010/823210 |
| spellingShingle | Jennifer Bishop Eric Brown Augusto Podesta Cathrine Troy Xiang (Eric) Dong Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature International Journal of Endocrinology |
| title | Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature |
| title_full | Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature |
| title_fullStr | Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature |
| title_full_unstemmed | Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature |
| title_short | Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature |
| title_sort | surgical management of calciphylaxis associated with primary hyperparathyroidism a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2010/823210 |
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