Association between Hypertension and Periodontitis: Possible Mechanisms
This review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxida...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/768237 |
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| author | Xin-Fang Leong Chun-Yi Ng Baharin Badiah Srijit Das |
| author_facet | Xin-Fang Leong Chun-Yi Ng Baharin Badiah Srijit Das |
| author_sort | Xin-Fang Leong |
| collection | DOAJ |
| description | This review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxidative stress and endothelial dysfunction are among the critical components in the development of hypertension. Inflammation has received much attention recently and may contribute to a pivotal role in hypertension. Periodontitis, a chronic low-grade inflammation of gingival tissue, has been linked to endothelial dysfunction, with blood pressure elevation and increased mortality risk in hypertensive patients. Inflammatory biomarkers are increased in hypertensive patients with periodontitis. Over the years, various researches have been performed to evaluate the involvement of periodontitis in the initiation and progression of hypertension. Many cross-sectional studies documented an association between hypertension and periodontitis. However, more well-designed prospective population trials need to be carried out to ascertain the role of periodontitis in hypertension. |
| format | Article |
| id | doaj-art-e5a548d19bee4a0eb3e356df212e128b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e5a548d19bee4a0eb3e356df212e128b2025-02-03T01:20:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/768237768237Association between Hypertension and Periodontitis: Possible MechanismsXin-Fang Leong0Chun-Yi Ng1Baharin Badiah2Srijit Das3Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Periodontology, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaThis review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxidative stress and endothelial dysfunction are among the critical components in the development of hypertension. Inflammation has received much attention recently and may contribute to a pivotal role in hypertension. Periodontitis, a chronic low-grade inflammation of gingival tissue, has been linked to endothelial dysfunction, with blood pressure elevation and increased mortality risk in hypertensive patients. Inflammatory biomarkers are increased in hypertensive patients with periodontitis. Over the years, various researches have been performed to evaluate the involvement of periodontitis in the initiation and progression of hypertension. Many cross-sectional studies documented an association between hypertension and periodontitis. However, more well-designed prospective population trials need to be carried out to ascertain the role of periodontitis in hypertension.http://dx.doi.org/10.1155/2014/768237 |
| spellingShingle | Xin-Fang Leong Chun-Yi Ng Baharin Badiah Srijit Das Association between Hypertension and Periodontitis: Possible Mechanisms The Scientific World Journal |
| title | Association between Hypertension and Periodontitis: Possible Mechanisms |
| title_full | Association between Hypertension and Periodontitis: Possible Mechanisms |
| title_fullStr | Association between Hypertension and Periodontitis: Possible Mechanisms |
| title_full_unstemmed | Association between Hypertension and Periodontitis: Possible Mechanisms |
| title_short | Association between Hypertension and Periodontitis: Possible Mechanisms |
| title_sort | association between hypertension and periodontitis possible mechanisms |
| url | http://dx.doi.org/10.1155/2014/768237 |
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