Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress
Bone is a hard, dynamically active tissue that continually rebuilds and maintains its mineral balance and structural integrity. Multiple mechanical properties of bone determine its ability to deform and fracture under load, as well as provide stable support and durability during motion. Meanwhile, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | EngMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S295048992500003X |
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| author | Wenbin Cai Yaya Huo Yu Liu Yan Su Haobo Guo Lijie Wang Bin Li Ting Liang |
| author_facet | Wenbin Cai Yaya Huo Yu Liu Yan Su Haobo Guo Lijie Wang Bin Li Ting Liang |
| author_sort | Wenbin Cai |
| collection | DOAJ |
| description | Bone is a hard, dynamically active tissue that continually rebuilds and maintains its mineral balance and structural integrity. Multiple mechanical properties of bone determine its ability to deform and fracture under load, as well as provide stable support and durability during motion. Meanwhile, the mechanical microenvironment within the bone can directly influence bone cells, whose perception of mechanical forces may enhance or inhibit various biological functions. Based on these mechanobiological processes, the mechanical design of biomaterials for bone repair and regeneration is becoming increasingly important. To achieve better clinical outcomes, bone repair materials should be selected based on the characteristics of the materials used in clinical application to achieve better outcomes. This review discusses the types of mechanical loading to which bone is subjected, how osteoblasts respond to such loading and the potential mechanisms involved, and the mechanical design of various biomaterials for bone repair. It then summarizes the progress made in bone-related biomechanical research and provides an outlook for future research efforts. |
| format | Article |
| id | doaj-art-e59fc5819d7c42d4a446ac0f2d079dc5 |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-e59fc5819d7c42d4a446ac0f2d079dc52025-01-31T05:12:53ZengElsevierEngMedicine2950-48992025-03-0121100057Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progressWenbin Cai0Yaya Huo1Yu Liu2Yan Su3Haobo Guo4Lijie Wang5Bin Li6Ting Liang7Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, ChinaMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, ChinaMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, ChinaMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, ChinaMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, ChinaSanitation & Environment Technology Institute of Soochow University Ltd, Suzhou, Jiangsu 215000, ChinaMedical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, China; Corresponding author. 178 Ganjiang Rd, Suzhou, Jiangsu, 215000, P. R. China.Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, China; Corresponding author. 178 Ganjiang Rd, Suzhou, Jiangsu, 215000, P. R. China.Bone is a hard, dynamically active tissue that continually rebuilds and maintains its mineral balance and structural integrity. Multiple mechanical properties of bone determine its ability to deform and fracture under load, as well as provide stable support and durability during motion. Meanwhile, the mechanical microenvironment within the bone can directly influence bone cells, whose perception of mechanical forces may enhance or inhibit various biological functions. Based on these mechanobiological processes, the mechanical design of biomaterials for bone repair and regeneration is becoming increasingly important. To achieve better clinical outcomes, bone repair materials should be selected based on the characteristics of the materials used in clinical application to achieve better outcomes. This review discusses the types of mechanical loading to which bone is subjected, how osteoblasts respond to such loading and the potential mechanisms involved, and the mechanical design of various biomaterials for bone repair. It then summarizes the progress made in bone-related biomechanical research and provides an outlook for future research efforts.http://www.sciencedirect.com/science/article/pii/S295048992500003XMechanical property of boneOsteoblastMechanobiologySignaling pathwayMechanical design of biomaterial |
| spellingShingle | Wenbin Cai Yaya Huo Yu Liu Yan Su Haobo Guo Lijie Wang Bin Li Ting Liang Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress EngMedicine Mechanical property of bone Osteoblast Mechanobiology Signaling pathway Mechanical design of biomaterial |
| title | Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress |
| title_full | Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress |
| title_fullStr | Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress |
| title_full_unstemmed | Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress |
| title_short | Biomechanics in bone regeneration and mechanobiology in osteoblasts: Fundamental concepts and recent progress |
| title_sort | biomechanics in bone regeneration and mechanobiology in osteoblasts fundamental concepts and recent progress |
| topic | Mechanical property of bone Osteoblast Mechanobiology Signaling pathway Mechanical design of biomaterial |
| url | http://www.sciencedirect.com/science/article/pii/S295048992500003X |
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