Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties
<i>Background and Objectives</i>: The purpose of this study was to evaluate potential protective effects of suramin on inflammation, oxidative stress, and histopathological damage a rat model of acute colitis created with acetic acid. <i>Materials and Methods</i>: Wistar albi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/5/829 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850257208655216640 |
|---|---|
| author | Gulcin Ercan Hatice Aygün Ahmet Akbaş Osman Sezer Çınaroğlu Oytun Erbas |
| author_facet | Gulcin Ercan Hatice Aygün Ahmet Akbaş Osman Sezer Çınaroğlu Oytun Erbas |
| author_sort | Gulcin Ercan |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The purpose of this study was to evaluate potential protective effects of suramin on inflammation, oxidative stress, and histopathological damage a rat model of acute colitis created with acetic acid. <i>Materials and Methods</i>: Wistar albino (male) rats were randomly assigned to three groups: control (n = 10), colitis + saline (n = 10), and colitis + suramin (n = 10). Rectal instillation of 4% acetic acid was used to induce acute colitis. Suramin (10 mg/kg/day) or saline was administered intraperitoneally for 15 days. Plasma concentrations of pentraxin 3 (PTX3), tumor necrosis factor-alpha (TNF-α), neutrophil extracellular traps (NETs), and malondialdehyde (MDA) were determined using enzyme-linked immunosorbent assay (ELISA) and spectrophotometric methods. In addition, vascular endothelial growth factor (VEGF) and TNF-α levels in colonic tissue were also measured. Histopathological evaluations were conducted using hematoxylin and eosin staining. <i>Results:</i> Significant increases in plasma and tissue inflammatory markers, oxidative stress parameters, and histopathological scores were observed when compared to control group; values were higher in colitis group. Suramin treatment significantly reduced plasma PTX3, TNF-α, NETs, and MDA levels, and colonic TNF-α and VEGF concentrations compared to the untreated colitis group. Histological analysis showed reduced epithelial injury and leukocyte presence in rats receiving suramin. <i>Conclusions</i>: Our findings demonstrate that suramin significantly attenuates inflammatory and oxidative damage in an experimental model of acute colitis. These results suggest that suramin may possess therapeutic potential in intestinal inflammation; however, this effect requires further support through advanced experimental and clinical studies. |
| format | Article |
| id | doaj-art-e59e1c7077494f4e901b8c16ec667230 |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-e59e1c7077494f4e901b8c16ec6672302025-08-20T01:56:28ZengMDPI AGMedicina1010-660X1648-91442025-04-0161582910.3390/medicina61050829Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory PropertiesGulcin Ercan0Hatice Aygün1Ahmet Akbaş2Osman Sezer Çınaroğlu3Oytun Erbas4Department of General Surgery, Sultan 2. Abdulhamid Han Educational and Research Hospital, Istanbul Provincial Directorate of Health, Istanbul 34865, TurkeyFaculty Medicine, Department of Physiology, Tokat Gaziosmanpaşa University, Tokat 60250, TurkeyDepartment of General Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, TurkeyDepartment of Emergency Medicine, Faculty of Medicine, Izmir Katip Çelebi University, Izmir 35620, TurkeyFaculty of Medicine, BAMER, Biruni University, Istanbul 34015, Türkiye<i>Background and Objectives</i>: The purpose of this study was to evaluate potential protective effects of suramin on inflammation, oxidative stress, and histopathological damage a rat model of acute colitis created with acetic acid. <i>Materials and Methods</i>: Wistar albino (male) rats were randomly assigned to three groups: control (n = 10), colitis + saline (n = 10), and colitis + suramin (n = 10). Rectal instillation of 4% acetic acid was used to induce acute colitis. Suramin (10 mg/kg/day) or saline was administered intraperitoneally for 15 days. Plasma concentrations of pentraxin 3 (PTX3), tumor necrosis factor-alpha (TNF-α), neutrophil extracellular traps (NETs), and malondialdehyde (MDA) were determined using enzyme-linked immunosorbent assay (ELISA) and spectrophotometric methods. In addition, vascular endothelial growth factor (VEGF) and TNF-α levels in colonic tissue were also measured. Histopathological evaluations were conducted using hematoxylin and eosin staining. <i>Results:</i> Significant increases in plasma and tissue inflammatory markers, oxidative stress parameters, and histopathological scores were observed when compared to control group; values were higher in colitis group. Suramin treatment significantly reduced plasma PTX3, TNF-α, NETs, and MDA levels, and colonic TNF-α and VEGF concentrations compared to the untreated colitis group. Histological analysis showed reduced epithelial injury and leukocyte presence in rats receiving suramin. <i>Conclusions</i>: Our findings demonstrate that suramin significantly attenuates inflammatory and oxidative damage in an experimental model of acute colitis. These results suggest that suramin may possess therapeutic potential in intestinal inflammation; however, this effect requires further support through advanced experimental and clinical studies.https://www.mdpi.com/1648-9144/61/5/829suraminanti-inflammatory activityantioxidant potentialacute experimental colitis |
| spellingShingle | Gulcin Ercan Hatice Aygün Ahmet Akbaş Osman Sezer Çınaroğlu Oytun Erbas Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties Medicina suramin anti-inflammatory activity antioxidant potential acute experimental colitis |
| title | Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties |
| title_full | Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties |
| title_fullStr | Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties |
| title_full_unstemmed | Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties |
| title_short | Suramin Exerts an Ameliorative Effect on Acetic Acid-Induced Acute Colitis in Rats by Demonstrating Potent Antioxidant and Anti-Inflammatory Properties |
| title_sort | suramin exerts an ameliorative effect on acetic acid induced acute colitis in rats by demonstrating potent antioxidant and anti inflammatory properties |
| topic | suramin anti-inflammatory activity antioxidant potential acute experimental colitis |
| url | https://www.mdpi.com/1648-9144/61/5/829 |
| work_keys_str_mv | AT gulcinercan suraminexertsanameliorativeeffectonaceticacidinducedacutecolitisinratsbydemonstratingpotentantioxidantandantiinflammatoryproperties AT haticeaygun suraminexertsanameliorativeeffectonaceticacidinducedacutecolitisinratsbydemonstratingpotentantioxidantandantiinflammatoryproperties AT ahmetakbas suraminexertsanameliorativeeffectonaceticacidinducedacutecolitisinratsbydemonstratingpotentantioxidantandantiinflammatoryproperties AT osmansezercınaroglu suraminexertsanameliorativeeffectonaceticacidinducedacutecolitisinratsbydemonstratingpotentantioxidantandantiinflammatoryproperties AT oytunerbas suraminexertsanameliorativeeffectonaceticacidinducedacutecolitisinratsbydemonstratingpotentantioxidantandantiinflammatoryproperties |