TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β‐catenin signaling through an increase in ILK expression

TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β‐catenin signaling through an increase in ILK expression

Abstract Transmembrane protein 182 (TMEM182) is notably abundant in muscle and adipose tissue, but its role in the heart remains unknown. This study examined the contribution of TMEM182 in the differentiation of human induced pluripotent stem cells (hiPSCs) into cardiomyocytes. For this, we generate...

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Bibliographic Details
Main Authors: Hirofumi Morihara, Shunichi Yokoe, Shigeo Wakabayashi, Shinji Takai
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:FASEB BioAdvances
Subjects:
hiPSCs
myocardial differentiation
TMEM182
Online Access:https://doi.org/10.1096/fba.2024-00086
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https://doi.org/10.1096/fba.2024-00086

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