GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway

GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway

Abstract Background Coronary heart disease (CHD) remains a global health threat. As antiplatelet therapy constitutes the cornerstone of CHD management, ticagrelor has been universally endorsed as a first-line agent in major clinical guidelines. However, the therapeutic efficacy of ticagrelor is comp...

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Bibliographic Details
Main Authors: Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
GPD2
DNA methylation
Epigenetic mechanism
ROS
NF-κB
P2Y12
Online Access:https://doi.org/10.1186/s11658-025-00759-x
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