Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort
Subject- and physician-reported data from 4,429 postmenopausal women receiving osteoporosis treatment in the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US) were used to assess the prevalence of risk factors (RFs) and on-study fracture. RFs assessed at st...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/715025 |
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| author | Nicole Yurgin Sally Wade Sacha Satram-Hoang David Macarios Marc Hochberg |
| author_facet | Nicole Yurgin Sally Wade Sacha Satram-Hoang David Macarios Marc Hochberg |
| author_sort | Nicole Yurgin |
| collection | DOAJ |
| description | Subject- and physician-reported data from 4,429 postmenopausal women receiving osteoporosis treatment in the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US) were used to assess the prevalence of risk factors (RFs) and on-study fracture. RFs assessed at study entry were age >70 years; fracture since age 50; minimum T-score (hip/spine) ≤−2.5 at diagnosis; body mass index <18.5 kg/m2; rheumatoid arthritis; parental history of hip fracture; current smoking; and recent oral glucocorticoid use. Data were collected with semiannual self-administered questionnaires. Results were stratified by physician-reported osteoporosis/osteopenia diagnosis. Low T-score and age >70 years were the most common RFs in the osteoporosis group, and age >70 years and prior fracture were the most common risk factors in the osteopenia group. Multiple RFs were more common than a single RF in osteoporotic women (54.2% versus 34.6%; P<0.0001) but not osteopenic women (13.8% versus 33.6%; P<0.0001). Women with multiple RFs had more on-study osteoporosis-related fractures than women with a single RF (osteoporosis group: 9.9% versus 6.2%; P=0.0092; osteopenia group: 11.2% versus 4.7%; P<0.0001). In postmenopausal women receiving osteoporosis treatment, multiple RFs increased fracture risk. RFs, in addition to bone mineral density, can help identify candidates for osteoporosis treatment. |
| format | Article |
| id | doaj-art-e59288782a174c72841ac7b338ffb643 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-e59288782a174c72841ac7b338ffb6432025-02-03T01:11:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/715025715025Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment CohortNicole Yurgin0Sally Wade1Sacha Satram-Hoang2David Macarios3Marc Hochberg4Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USAWade Outcomes Research and Consulting, 358 South 700 East, Suite B432, Salt Lake City, UT 84102, USAQ.D. Research, Inc., 8789 Auburn Folsom Road, Suite C501, Granite Bay, CA 95746, USAAmgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USADivision of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, 10 S. Pine Street, MSTF 8-34, Baltimore, MD 21201, USASubject- and physician-reported data from 4,429 postmenopausal women receiving osteoporosis treatment in the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US) were used to assess the prevalence of risk factors (RFs) and on-study fracture. RFs assessed at study entry were age >70 years; fracture since age 50; minimum T-score (hip/spine) ≤−2.5 at diagnosis; body mass index <18.5 kg/m2; rheumatoid arthritis; parental history of hip fracture; current smoking; and recent oral glucocorticoid use. Data were collected with semiannual self-administered questionnaires. Results were stratified by physician-reported osteoporosis/osteopenia diagnosis. Low T-score and age >70 years were the most common RFs in the osteoporosis group, and age >70 years and prior fracture were the most common risk factors in the osteopenia group. Multiple RFs were more common than a single RF in osteoporotic women (54.2% versus 34.6%; P<0.0001) but not osteopenic women (13.8% versus 33.6%; P<0.0001). Women with multiple RFs had more on-study osteoporosis-related fractures than women with a single RF (osteoporosis group: 9.9% versus 6.2%; P=0.0092; osteopenia group: 11.2% versus 4.7%; P<0.0001). In postmenopausal women receiving osteoporosis treatment, multiple RFs increased fracture risk. RFs, in addition to bone mineral density, can help identify candidates for osteoporosis treatment.http://dx.doi.org/10.1155/2013/715025 |
| spellingShingle | Nicole Yurgin Sally Wade Sacha Satram-Hoang David Macarios Marc Hochberg Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort International Journal of Endocrinology |
| title | Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort |
| title_full | Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort |
| title_fullStr | Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort |
| title_full_unstemmed | Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort |
| title_short | Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort |
| title_sort | prevalence of fracture risk factors in postmenopausal women enrolled in the possible us treatment cohort |
| url | http://dx.doi.org/10.1155/2013/715025 |
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