Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release
This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such mate...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/9176257 |
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| _version_ | 1832547814971801600 |
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| author | Abdullah M. Alswieleh |
| author_facet | Abdullah M. Alswieleh |
| author_sort | Abdullah M. Alswieleh |
| collection | DOAJ |
| description | This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca. 35% in 90 min in acidic media. |
| format | Article |
| id | doaj-art-e5913b8e316f4dee99e7f113d72154f2 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e5913b8e316f4dee99e7f113d72154f22025-02-03T06:43:27ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/91762579176257Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug ReleaseAbdullah M. Alswieleh0Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaThis paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca. 35% in 90 min in acidic media.http://dx.doi.org/10.1155/2020/9176257 |
| spellingShingle | Abdullah M. Alswieleh Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release Journal of Chemistry |
| title | Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release |
| title_full | Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release |
| title_fullStr | Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release |
| title_full_unstemmed | Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release |
| title_short | Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release |
| title_sort | modification of mesoporous silica surface by immobilization of functional groups for controlled drug release |
| url | http://dx.doi.org/10.1155/2020/9176257 |
| work_keys_str_mv | AT abdullahmalswieleh modificationofmesoporoussilicasurfacebyimmobilizationoffunctionalgroupsforcontrolleddrugrelease |