Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms
Aim. The outbreak of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic, with the main manifestations being of respiratory nature, including pneumonia. It is noteworthy that digestive symptoms are also observed in COVID-19 patients. In this article, we describe the immuno-inflamma...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/1063254 |
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| author | Caihan Duan Shengyan Zhang Jian Wang Wei Qian Chaoqun Han Xiaohua Hou |
| author_facet | Caihan Duan Shengyan Zhang Jian Wang Wei Qian Chaoqun Han Xiaohua Hou |
| author_sort | Caihan Duan |
| collection | DOAJ |
| description | Aim. The outbreak of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic, with the main manifestations being of respiratory nature, including pneumonia. It is noteworthy that digestive symptoms are also observed in COVID-19 patients. In this article, we describe the immuno-inflammatory characteristics of low severity COVID-19 patients with digestive symptoms. Methods. Patients with mild symptoms of COVID-19 were split into three groups based on the patients’ symptoms. The first group displayed digestive symptoms only, the second group displayed respiratory symptoms only, and the last group displayed both digestive and respiratory symptoms. Patients were discharged based on negative results of rRT-PCR testing for SARS-CoV-2 from at least two sequential respiratory tract specimens collected ≥24 hours apart. Multiorgan function and immuno-inflammatory characteristics were analyzed for all of the three groups. Results. Mild liver damage and activation of the immuno-inflammatory system were the most common abnormalities observed in patients with mild COVID-19 symptoms but no significant differences were found (P>0.05). Patients with digestive symptoms were more likely to have slightly higher and later peak values of inflammatory cytokines during the subsequent course of disease (P<0.05). In addition, a significant correlation between IL-2 and TNF level was found in the first group which included patients with digestive symptoms only (P<0.05). Conclusions. Patients with mild cases of COVID-19 only displaying digestive symptoms are a special subtype. Patients in this group were more likely to have slightly higher and delayed peak values of inflammatory cytokines during the subsequent course of the disease. Prevention and clinical management of this type should be taken into consideration. |
| format | Article |
| id | doaj-art-e590908247fa4781bfaddb627eb34a7c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e590908247fa4781bfaddb627eb34a7c2025-02-03T01:20:09ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/10632541063254Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive SymptomsCaihan Duan0Shengyan Zhang1Jian Wang2Wei Qian3Chaoqun Han4Xiaohua Hou5Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaAim. The outbreak of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic, with the main manifestations being of respiratory nature, including pneumonia. It is noteworthy that digestive symptoms are also observed in COVID-19 patients. In this article, we describe the immuno-inflammatory characteristics of low severity COVID-19 patients with digestive symptoms. Methods. Patients with mild symptoms of COVID-19 were split into three groups based on the patients’ symptoms. The first group displayed digestive symptoms only, the second group displayed respiratory symptoms only, and the last group displayed both digestive and respiratory symptoms. Patients were discharged based on negative results of rRT-PCR testing for SARS-CoV-2 from at least two sequential respiratory tract specimens collected ≥24 hours apart. Multiorgan function and immuno-inflammatory characteristics were analyzed for all of the three groups. Results. Mild liver damage and activation of the immuno-inflammatory system were the most common abnormalities observed in patients with mild COVID-19 symptoms but no significant differences were found (P>0.05). Patients with digestive symptoms were more likely to have slightly higher and later peak values of inflammatory cytokines during the subsequent course of disease (P<0.05). In addition, a significant correlation between IL-2 and TNF level was found in the first group which included patients with digestive symptoms only (P<0.05). Conclusions. Patients with mild cases of COVID-19 only displaying digestive symptoms are a special subtype. Patients in this group were more likely to have slightly higher and delayed peak values of inflammatory cytokines during the subsequent course of the disease. Prevention and clinical management of this type should be taken into consideration.http://dx.doi.org/10.1155/2020/1063254 |
| spellingShingle | Caihan Duan Shengyan Zhang Jian Wang Wei Qian Chaoqun Han Xiaohua Hou Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms Gastroenterology Research and Practice |
| title | Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms |
| title_full | Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms |
| title_fullStr | Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms |
| title_full_unstemmed | Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms |
| title_short | Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms |
| title_sort | immuno inflammatory characteristics in low severity covid 19 patients with digestive symptoms |
| url | http://dx.doi.org/10.1155/2020/1063254 |
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