Age‐Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All‐Cause Mortality in a Sardinian Population Cohort

Age‐Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All‐Cause Mortality in a Sardinian Population Cohort

Background Growth differentiation factor 15 (GDF‐15) levels are emerging as a candidate biomarker of aging. The present study aimed to: (1) characterize the association of GDF‐15 with the continuum of arterial stiffening, assessed as carotid‐femoral pulse wave velocity, as age increases; (2) determi...

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Main Authors: Richard Oppong, Valeria Orru, Michele Marongiu, Yong Qian, Carlo Sidore, Alessandro Delitala, Marco Orru, Antonella Mulas, Maria Grazia Piras, Christopher H. Morrell, Sandra Lai, David Schlessinger, Myriam Gorospe, Francesco Cucca, Edoardo Fiorillo, Jun Ding, Edward G. Lakatta, Angelo Scuteri
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aging
central arterial stiffness
GDF‐15
genetic markers
pulse wave velocity
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036253
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