Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents
Background: Peripheral arterial disease (PAD) is a common source of morbidity and mortality globally and is expected to raise increase in prevalence. Many endovascular techniques exist to manage PAD; however, there remains room for improvement, especially as it relates to below-the-knee vessels. Rec...
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Elsevier
2025-01-01
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| Series: | JVS - Vascular Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666350324000889 |
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| author | Blair E. Warren, MD, MSCS Kong-Teng Tan, MD Dheeraj K. Rajan, MD Miranda Witheford, MD, PhD Sean Crawford, MD, MSc Arash Jaberi, MD, MEd Sebastian Mafeld, MBBS |
| author_facet | Blair E. Warren, MD, MSCS Kong-Teng Tan, MD Dheeraj K. Rajan, MD Miranda Witheford, MD, PhD Sean Crawford, MD, MSc Arash Jaberi, MD, MEd Sebastian Mafeld, MBBS |
| author_sort | Blair E. Warren, MD, MSCS |
| collection | DOAJ |
| description | Background: Peripheral arterial disease (PAD) is a common source of morbidity and mortality globally and is expected to raise increase in prevalence. Many endovascular techniques exist to manage PAD; however, there remains room for improvement, especially as it relates to below-the-knee vessels. Recent evidence and devices are leading to a resurgence of interest in bioresorbable vascular scaffolds and the -limus family of antiproliferative drugs in the PAD treatment space. Methods: This nonsystematic review examines emerging technology for treatment of PAD with a specific focus on below-the-knee vessels and bioresorbable vascular scaffolds. Additional emerging and early technology such as novel delivery platforms are also briefly discussed with directions of future research highlighted. Results: Bioresorbable vascular scaffold biomechanics and history are highlighted. Foundational knowledge of antiproliferative agents and evolving agents in peripheral vascular disease are also described. Conclusions: Bioresorbable vascular scaffolds are an additional endovascular tool for the treatment of peripheral vascular disease. The integration with an antiproliferative agent may result in improved patency and performance; however, there is a paucity of data in the literature at present. |
| format | Article |
| id | doaj-art-e58dc4bc49b541d89e256186cf9a5b35 |
| institution | Kabale University |
| issn | 2666-3503 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JVS - Vascular Science |
| spelling | doaj-art-e58dc4bc49b541d89e256186cf9a5b352025-01-23T05:27:47ZengElsevierJVS - Vascular Science2666-35032025-01-016100277Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agentsBlair E. Warren, MD, MSCS0Kong-Teng Tan, MD1Dheeraj K. Rajan, MD2Miranda Witheford, MD, PhD3Sean Crawford, MD, MSc4Arash Jaberi, MD, MEd5Sebastian Mafeld, MBBS6Department of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada; Correspondence: Blair E. Warren, MD, MSCS, Joint Department of Medical Imaging, University Health Network, 200 Elizabeth St, Peter Munk Building, 1st Fl, Toronto, Ontario M5G 2C4, CanadaDepartment of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, CanadaDepartment of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, CanadaDivision of Vascular Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, CanadaDivision of Vascular Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, CanadaDepartment of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, CanadaDepartment of Medical Imaging, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Vascular and Interventional Radiology, Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, CanadaBackground: Peripheral arterial disease (PAD) is a common source of morbidity and mortality globally and is expected to raise increase in prevalence. Many endovascular techniques exist to manage PAD; however, there remains room for improvement, especially as it relates to below-the-knee vessels. Recent evidence and devices are leading to a resurgence of interest in bioresorbable vascular scaffolds and the -limus family of antiproliferative drugs in the PAD treatment space. Methods: This nonsystematic review examines emerging technology for treatment of PAD with a specific focus on below-the-knee vessels and bioresorbable vascular scaffolds. Additional emerging and early technology such as novel delivery platforms are also briefly discussed with directions of future research highlighted. Results: Bioresorbable vascular scaffold biomechanics and history are highlighted. Foundational knowledge of antiproliferative agents and evolving agents in peripheral vascular disease are also described. Conclusions: Bioresorbable vascular scaffolds are an additional endovascular tool for the treatment of peripheral vascular disease. The integration with an antiproliferative agent may result in improved patency and performance; however, there is a paucity of data in the literature at present.http://www.sciencedirect.com/science/article/pii/S2666350324000889Peripheral vascular diseaseBioresorbable vascular scaffoldsStentsAngioplasty |
| spellingShingle | Blair E. Warren, MD, MSCS Kong-Teng Tan, MD Dheeraj K. Rajan, MD Miranda Witheford, MD, PhD Sean Crawford, MD, MSc Arash Jaberi, MD, MEd Sebastian Mafeld, MBBS Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents JVS - Vascular Science Peripheral vascular disease Bioresorbable vascular scaffolds Stents Angioplasty |
| title | Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents |
| title_full | Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents |
| title_fullStr | Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents |
| title_full_unstemmed | Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents |
| title_short | Moving away from metal: Step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents |
| title_sort | moving away from metal step toward the future with bioresorbable vascular scaffolds and novel antiproliferative agents |
| topic | Peripheral vascular disease Bioresorbable vascular scaffolds Stents Angioplasty |
| url | http://www.sciencedirect.com/science/article/pii/S2666350324000889 |
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