Elastography in Hepatology

A common characteristic of all chronic liver diseases is the occurrence and progression of fibrosis toward cirrhosis. Consequently, liver fibrosis assessment plays an important role in hepatology. Besides its importance for prognosis, determining the level of fibrosis reveals the natural history of...

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Main Authors: Ludovico Abenavoli, Christophe Corpechot, Raoul Poupon
Format: Article
Language:English
Published: Wiley 2007-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2007/621489
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author Ludovico Abenavoli
Christophe Corpechot
Raoul Poupon
author_facet Ludovico Abenavoli
Christophe Corpechot
Raoul Poupon
author_sort Ludovico Abenavoli
collection DOAJ
description A common characteristic of all chronic liver diseases is the occurrence and progression of fibrosis toward cirrhosis. Consequently, liver fibrosis assessment plays an important role in hepatology. Besides its importance for prognosis, determining the level of fibrosis reveals the natural history of the disease and the risk factors associated with its progression, to guide the antifibrotic action of different treatments. Currently, in clinical practice, there are three available methods for the evaluation of liver fibrosis: liver biopsy, which is still considered to be the ‘gold standard’; serological markers of fibrosis and their mathematical combination – suggested in recent years to be an alternative to liver biopsy – and, more recently, transient elastography (TE). TE is a new, simple and noninvasive method used to measure liver stiffness. This technique is based on the progressing speed of an elastic shear wave within the liver. Currently, there are only a few studies that have evaluated TE effectiveness in chronic liver diseases, mostly in patients infected with the hepatitis C virus. Further studies are needed in patients with chronic liver disease, to assess the effectiveness of the fibrosis treatment.
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spelling doaj-art-e585a68730874c69a4c3bf3771ef48452025-02-03T06:13:59ZengWileyCanadian Journal of Gastroenterology0835-79002007-01-01211283984210.1155/2007/621489Elastography in HepatologyLudovico Abenavoli0Christophe Corpechot1Raoul Poupon2Istituto di Medicina Interna, Università Cattolica del S. Cuore, Roma, ItalyService d’Hépatologie, Centre national de référence des maladies inflammatoires du foie et des voies biliaires, Hôpital S. Antoine, Paris, FranceService d’Hépatologie, Centre national de référence des maladies inflammatoires du foie et des voies biliaires, Hôpital S. Antoine, Paris, FranceA common characteristic of all chronic liver diseases is the occurrence and progression of fibrosis toward cirrhosis. Consequently, liver fibrosis assessment plays an important role in hepatology. Besides its importance for prognosis, determining the level of fibrosis reveals the natural history of the disease and the risk factors associated with its progression, to guide the antifibrotic action of different treatments. Currently, in clinical practice, there are three available methods for the evaluation of liver fibrosis: liver biopsy, which is still considered to be the ‘gold standard’; serological markers of fibrosis and their mathematical combination – suggested in recent years to be an alternative to liver biopsy – and, more recently, transient elastography (TE). TE is a new, simple and noninvasive method used to measure liver stiffness. This technique is based on the progressing speed of an elastic shear wave within the liver. Currently, there are only a few studies that have evaluated TE effectiveness in chronic liver diseases, mostly in patients infected with the hepatitis C virus. Further studies are needed in patients with chronic liver disease, to assess the effectiveness of the fibrosis treatment.http://dx.doi.org/10.1155/2007/621489
spellingShingle Ludovico Abenavoli
Christophe Corpechot
Raoul Poupon
Elastography in Hepatology
Canadian Journal of Gastroenterology
title Elastography in Hepatology
title_full Elastography in Hepatology
title_fullStr Elastography in Hepatology
title_full_unstemmed Elastography in Hepatology
title_short Elastography in Hepatology
title_sort elastography in hepatology
url http://dx.doi.org/10.1155/2007/621489
work_keys_str_mv AT ludovicoabenavoli elastographyinhepatology
AT christophecorpechot elastographyinhepatology
AT raoulpoupon elastographyinhepatology