Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.

Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.

During prion infections of the central nervous system (CNS) the cellular prion protein, PrP(C), is templated to a conformationally distinct form, PrP(Sc). Recent studies have demonstrated that the Sprn gene encodes a GPI-linked glycoprotein Shadoo (Sho), which localizes to a similar membrane environ...

Full description

Saved in:
Bibliographic Details
Main Authors: David Westaway, Sacha Genovesi, Nathalie Daude, Rebecca Brown, Agnes Lau, Inyoul Lee, Charles E Mays, Janaky Coomaraswamy, Brenda Canine, Rose Pitstick, Allen Herbst, Jing Yang, Kerry W S Ko, Gerold Schmitt-Ulms, Stephen J Dearmond, Debbie McKenzie, Leroy Hood, George A Carlson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002391&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002391&type=printable

Similar Items