Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis
Background. Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules whi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/9254374 |
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| author | Wolfgang Jungraithmayr Stefanos Tzafos Oliver Distler Antonios G. A. Kolios Walter Weder Daniel Franzen |
| author_facet | Wolfgang Jungraithmayr Stefanos Tzafos Oliver Distler Antonios G. A. Kolios Walter Weder Daniel Franzen |
| author_sort | Wolfgang Jungraithmayr |
| collection | DOAJ |
| description | Background. Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules which, as a differential diagnosis, can mimic metastatic disease or multiple abscesses. Case Presentation. We present the case of a 62-year old former pit worker with pulmonary nodules, chondrocalcinosis due to calcium pyrophosphate deposition (CPPD), and a history of renal cancer. Within a short period of time, pulmonary nodules grew rapidly. Thoracoscopically, the resected lung specimen revealed silicoanthracosis associated with small-to-medium-size vasculitis in the presence of antineutrophil cytoplasmatic autoantibodies (c-ANCA). Conclusion. Pulmonary silicoanthracotic lesions on the base of ANCA-associated vasculitis and CPPD arthritis can rapidly grow. A mutual correlation between silicoanthracosis, ANCA-associated vasculitis, and CPPD seems possible. Apart from this, consideration of metastatic disease should be obligatory in patients with a history of cancer at the same time being immunosuppressed. |
| format | Article |
| id | doaj-art-e57e2908add5415cab79fe02a62033cc |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-e57e2908add5415cab79fe02a62033cc2025-02-03T05:45:51ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/92543749254374Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and ChondrocalcinosisWolfgang Jungraithmayr0Stefanos Tzafos1Oliver Distler2Antonios G. A. Kolios3Walter Weder4Daniel Franzen5Division of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091 Zurich, SwitzerlandDivision of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091 Zurich, SwitzerlandDepartment of Rheumatology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, SwitzerlandDepartment of Immunology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, SwitzerlandDivision of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091 Zurich, SwitzerlandDivision of Pulmonology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, SwitzerlandBackground. Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules which, as a differential diagnosis, can mimic metastatic disease or multiple abscesses. Case Presentation. We present the case of a 62-year old former pit worker with pulmonary nodules, chondrocalcinosis due to calcium pyrophosphate deposition (CPPD), and a history of renal cancer. Within a short period of time, pulmonary nodules grew rapidly. Thoracoscopically, the resected lung specimen revealed silicoanthracosis associated with small-to-medium-size vasculitis in the presence of antineutrophil cytoplasmatic autoantibodies (c-ANCA). Conclusion. Pulmonary silicoanthracotic lesions on the base of ANCA-associated vasculitis and CPPD arthritis can rapidly grow. A mutual correlation between silicoanthracosis, ANCA-associated vasculitis, and CPPD seems possible. Apart from this, consideration of metastatic disease should be obligatory in patients with a history of cancer at the same time being immunosuppressed.http://dx.doi.org/10.1155/2016/9254374 |
| spellingShingle | Wolfgang Jungraithmayr Stefanos Tzafos Oliver Distler Antonios G. A. Kolios Walter Weder Daniel Franzen Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis Canadian Respiratory Journal |
| title | Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis |
| title_full | Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis |
| title_fullStr | Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis |
| title_full_unstemmed | Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis |
| title_short | Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis |
| title_sort | rapid growth of lung nodules due to combined pulmonary vasculitis silicoanthracosis and chondrocalcinosis |
| url | http://dx.doi.org/10.1155/2016/9254374 |
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