Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy
Continuous glucose monitoring (CGM) might be an effective tool to improve glycemic control in gestational diabetes mellitus (GDM). Few data are available about its utilization as a diagnostic tool to find potential alterations of glycemia in subjects with normal oral glucose tolerance test (OGTT). I...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9987646 |
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| author | Linda Tartaglione Enrico di Stasio Angelo Sirico Mauro Di Leo Salvatore Caputo Alessandro Rizzi Agnese Caneschi Sara De Carolis Dario Pitocco Antonio Lanzone |
| author_facet | Linda Tartaglione Enrico di Stasio Angelo Sirico Mauro Di Leo Salvatore Caputo Alessandro Rizzi Agnese Caneschi Sara De Carolis Dario Pitocco Antonio Lanzone |
| author_sort | Linda Tartaglione |
| collection | DOAJ |
| description | Continuous glucose monitoring (CGM) might be an effective tool to improve glycemic control in gestational diabetes mellitus (GDM). Few data are available about its utilization as a diagnostic tool to find potential alterations of glycemia in subjects with normal oral glucose tolerance test (OGTT). In this preliminary prospective real-life observational study, we aimed to analyze the glycemic pattern in normal and gestational diabetes mellitus (GDM) women by continuous glucose monitoring (CGM) in order to detect potential differences between the two groups and glycemic alterations despite a normal OGTT. After the screening for GDM, subjects were connected to a CGM system for seven consecutive days. The areas under the curve of the first 60 minutes after each meal and 60 minutes before breakfast were analyzed. Women with normal OGTT that during CGM showed impaired glycemic values (more than 95 fasting or more than 140 one hour after meals or more than 120 two hours after meals) performed one week of self-monitoring of blood glucose (SMBG). After OGTT, 53 women considered normal and 46 affected by GDM were included. CGM parameters did not show any differences between the two groups with impaired glycemic excursions found in both groups. After CGM period, 33 women with normal OGTT showed abnormal glycemic patterns. These 33 women then performed one week of SMBG. After evaluation of one week of SMBG, 21 required diet therapy and 12 required insulin treatment and were followed until the delivery. An increase in gestational weight gain was observed in normal women with normal OGTT but this was not significant. No significant data were found regarding neonatal outcomes in the two groups of women. In conclusion, CGM use in pregnancy might help to detect glycemic fluctuations in women with normal OGTT, improving their treatment and outcomes. |
| format | Article |
| id | doaj-art-e57ce71697844130a2bfe1bfd02665e5 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e57ce71697844130a2bfe1bfd02665e52025-02-03T01:25:08ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/99876469987646Continuous Glucose Monitoring in Women with Normal OGTT in PregnancyLinda Tartaglione0Enrico di Stasio1Angelo Sirico2Mauro Di Leo3Salvatore Caputo4Alessandro Rizzi5Agnese Caneschi6Sara De Carolis7Dario Pitocco8Antonio Lanzone9Diabetes Care Unit, Department of Endocrinology and Diabetes, Catholic University of Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDepartment of Clinical Biochemistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDepartment of Obstetrics and Gynecology, Catholic University of Sacred Heart, Fondazione Polclinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDiabetes Care Unit, Department of Endocrinology and Diabetes, Catholic University of Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDiabetes Care Unit, Department of Endocrinology and Diabetes, Catholic University of Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDiabetes Care Unit, Department of Endocrinology and Diabetes, Catholic University of Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDepartment of Obstetrics and Gynecology, Catholic University of Sacred Heart, Fondazione Polclinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDepartment of Obstetrics and Gynecology, Catholic University of Sacred Heart, Fondazione Polclinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDiabetes Care Unit, Department of Endocrinology and Diabetes, Catholic University of Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDepartment of Obstetrics and Gynecology, Catholic University of Sacred Heart, Fondazione Polclinico Universitario Agostino Gemelli IRCCS, Rome, ItalyContinuous glucose monitoring (CGM) might be an effective tool to improve glycemic control in gestational diabetes mellitus (GDM). Few data are available about its utilization as a diagnostic tool to find potential alterations of glycemia in subjects with normal oral glucose tolerance test (OGTT). In this preliminary prospective real-life observational study, we aimed to analyze the glycemic pattern in normal and gestational diabetes mellitus (GDM) women by continuous glucose monitoring (CGM) in order to detect potential differences between the two groups and glycemic alterations despite a normal OGTT. After the screening for GDM, subjects were connected to a CGM system for seven consecutive days. The areas under the curve of the first 60 minutes after each meal and 60 minutes before breakfast were analyzed. Women with normal OGTT that during CGM showed impaired glycemic values (more than 95 fasting or more than 140 one hour after meals or more than 120 two hours after meals) performed one week of self-monitoring of blood glucose (SMBG). After OGTT, 53 women considered normal and 46 affected by GDM were included. CGM parameters did not show any differences between the two groups with impaired glycemic excursions found in both groups. After CGM period, 33 women with normal OGTT showed abnormal glycemic patterns. These 33 women then performed one week of SMBG. After evaluation of one week of SMBG, 21 required diet therapy and 12 required insulin treatment and were followed until the delivery. An increase in gestational weight gain was observed in normal women with normal OGTT but this was not significant. No significant data were found regarding neonatal outcomes in the two groups of women. In conclusion, CGM use in pregnancy might help to detect glycemic fluctuations in women with normal OGTT, improving their treatment and outcomes.http://dx.doi.org/10.1155/2021/9987646 |
| spellingShingle | Linda Tartaglione Enrico di Stasio Angelo Sirico Mauro Di Leo Salvatore Caputo Alessandro Rizzi Agnese Caneschi Sara De Carolis Dario Pitocco Antonio Lanzone Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy Journal of Diabetes Research |
| title | Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy |
| title_full | Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy |
| title_fullStr | Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy |
| title_full_unstemmed | Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy |
| title_short | Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy |
| title_sort | continuous glucose monitoring in women with normal ogtt in pregnancy |
| url | http://dx.doi.org/10.1155/2021/9987646 |
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