Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene

Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene

Background: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In the absen...

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Main Authors: Marcella M. Baldewijns, Iris J. H. van Vlodrop, Kim M. Smits, Peter B. Vermeulen, Gert G. Van den Eynden, Fiona Schot, Tania Roskams, Hein van Poppel, Manon van Engeland, Adriaan P. de Bruïne
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2009-0482
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