Cardioprotective Effect of Growth Differentiation Factor 15 Against Isoproterenol-Induced Cardiomyocyte Apoptosis via Regulation of the Mitochondrial Fusion

Cardioprotective Effect of Growth Differentiation Factor 15 Against Isoproterenol-Induced Cardiomyocyte Apoptosis via Regulation of the Mitochondrial Fusion

Abstract. Objective:. Pressure overload-induced myocardial apoptosis is a critical pathologically initiated process leading to heart failure (HF). Growth differentiation factor 15 (GDF15) dramatically increases during cardiac hypertrophy and dysfunction, but its functions and mechanisms are barely k...

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Main Authors: Yan Zhang, Zhu Mei, Xiaodong Jia, Haixu Song, Jing Liu, Xiaoxiang Tian, Tianyu Xu, Xiaoxia Fu
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2022-06-01
Series:Cardiology Discovery
Online Access:http://journals.lww.com/10.1097/CD9.0000000000000051
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