Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients
Background. Helicobacter pylori chronically colonizes gastric/duodenal mucosa and induces gastroduodenal disease and vigorous humoral and cellular immune responses. Methods. In order to clarify the immunological changes induced by this infection, we determined the percentage and, as indicated, ratio...
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/819842 |
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| author | Yuka Satoh Hatsue Ogawara Osamu Kawamura Motoyasu Kusano Hirokazu Murakami |
| author_facet | Yuka Satoh Hatsue Ogawara Osamu Kawamura Motoyasu Kusano Hirokazu Murakami |
| author_sort | Yuka Satoh |
| collection | DOAJ |
| description | Background. Helicobacter pylori chronically colonizes gastric/duodenal mucosa and induces gastroduodenal disease and vigorous humoral and cellular immune responses. Methods. In order to clarify the immunological changes induced by this infection, we determined the percentage and, as indicated, ratios of the following cells in peripheral blood of 45 H. pylori-infected patients and 21 control subjects: CD4+ T cell, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Tregs), CD4/CD8 ratio, and Th1/Th2 ratio.
Results. The percentage of CD8+ T cells was significantly lower in H. pylori-infected patients (mean±SD; 18.0±7.1%) compared to control subjects (mean±SD; 23.2±7.8%) (𝑃<0.05). The CD4/CD8 ratio was significantly higher in H. pylori-infected patients (mean±SD; 3.1±2.4) compared to control subjects (mean±SD; 2.1±1.0) (𝑃<0.05). The Th1/Th2 ratio was significantly lower in H. pylori-infected patients (mean±SD; 10.0±8.5) compared to control subjects (mean±SD; 14.5±9.0) (𝑃<0.05). The percentage of CD4+CD25+ T cells in H. pylori-infected patients (mean±SD; 13.2±6.2%) was significantly higher than that in control subjects (mean±SD; 9.8±3.4%) (𝑃<0.05). However, there was no significant difference in Tregs. Conclusion. Tregs did not decrease, but the activation of humoral immunity and Th2 polarization were observed in the peripheral blood of H. pylori-infected patients. In some cases, these changes may induce systemic autoimmune diseases. |
| format | Article |
| id | doaj-art-e560f467e870455badd63e50d40ba930 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e560f467e870455badd63e50d40ba9302025-02-03T05:44:55ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/819842819842Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected PatientsYuka Satoh0Hatsue Ogawara1Osamu Kawamura2Motoyasu Kusano3Hirokazu Murakami4Department of Laboratory Sciences, Course of Health Sciences, Gunma Graduate School of Health Sciences, Showa-machi 3-39-22, Maebasi 371-8514, Gunma, JapanDepartment of Laboratory Sciences, Course of Health Sciences, Gunma Graduate School of Health Sciences, Showa-machi 3-39-22, Maebasi 371-8514, Gunma, JapanDepartment of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Maebasi 371-8511, Gunma, JapanDepartment of Endoscopy and Endoscopic Surgery, Gunma University Hospital Showa-machi 3-39-15, Maebasi 371-8511, Gunma, JapanDepartment of Laboratory Sciences, Course of Health Sciences, Gunma Graduate School of Health Sciences, Showa-machi 3-39-22, Maebasi 371-8514, Gunma, JapanBackground. Helicobacter pylori chronically colonizes gastric/duodenal mucosa and induces gastroduodenal disease and vigorous humoral and cellular immune responses. Methods. In order to clarify the immunological changes induced by this infection, we determined the percentage and, as indicated, ratios of the following cells in peripheral blood of 45 H. pylori-infected patients and 21 control subjects: CD4+ T cell, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Tregs), CD4/CD8 ratio, and Th1/Th2 ratio. Results. The percentage of CD8+ T cells was significantly lower in H. pylori-infected patients (mean±SD; 18.0±7.1%) compared to control subjects (mean±SD; 23.2±7.8%) (𝑃<0.05). The CD4/CD8 ratio was significantly higher in H. pylori-infected patients (mean±SD; 3.1±2.4) compared to control subjects (mean±SD; 2.1±1.0) (𝑃<0.05). The Th1/Th2 ratio was significantly lower in H. pylori-infected patients (mean±SD; 10.0±8.5) compared to control subjects (mean±SD; 14.5±9.0) (𝑃<0.05). The percentage of CD4+CD25+ T cells in H. pylori-infected patients (mean±SD; 13.2±6.2%) was significantly higher than that in control subjects (mean±SD; 9.8±3.4%) (𝑃<0.05). However, there was no significant difference in Tregs. Conclusion. Tregs did not decrease, but the activation of humoral immunity and Th2 polarization were observed in the peripheral blood of H. pylori-infected patients. In some cases, these changes may induce systemic autoimmune diseases.http://dx.doi.org/10.1155/2012/819842 |
| spellingShingle | Yuka Satoh Hatsue Ogawara Osamu Kawamura Motoyasu Kusano Hirokazu Murakami Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients Gastroenterology Research and Practice |
| title | Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients |
| title_full | Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients |
| title_fullStr | Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients |
| title_full_unstemmed | Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients |
| title_short | Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients |
| title_sort | clinical significance of peripheral blood t lymphocyte subsets in helicobacter pylori infected patients |
| url | http://dx.doi.org/10.1155/2012/819842 |
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