Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy
Objective. Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy. Methods. Participants underwe...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2023/7768980 |
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| author | Yajin Huang Yaqing Liu Wenjun Song Yanjun Liu Xiaoqian Wang Juping Han Jiang Ye Hongmei Han Li Wang Juan Li Tiancheng Wang |
| author_facet | Yajin Huang Yaqing Liu Wenjun Song Yanjun Liu Xiaoqian Wang Juping Han Jiang Ye Hongmei Han Li Wang Juan Li Tiancheng Wang |
| author_sort | Yajin Huang |
| collection | DOAJ |
| description | Objective. Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy. Methods. Participants underwent one-night sleep electroencephalogram recording and neuropsychological tests on the same day. Spindle characteristics during N2 sleep were extracted using a learning-based system for sleep staging and an automated spindle detection algorithm. We investigated the difference between cognitive subgroups in spindle characteristics. Multiple linear regressions were applied to analyze associations between cognition and spindle characteristics. Results. Compared with no/mild cognitive impairment, epilepsy patients who developed severe cognitive impairment had lower sleep spindle density, the differences mainly distributed in central, occipital, parietal, middle temporal, and posterior temporal (P<0.05), and had relatively long spindle duration in occipital and posterior temporal P<0.05. Mini-Mental State Examination (MMSE) was associated with spindle density (pars triangularis of the inferior frontal gyrus (IFGtri): β=0.253, P=0.015, and P.adjust=0.074) and spindle duration (IFGtri: β=−0.262, P=0.004, and P.adjust=0.030). Montreal Cognitive Assessment (MoCA) was associated with spindle duration (IFGtri: β=−0.246, P=0.010, and P.adjust=0.055). Executive Index Score (MoCA-EIS) was associated with spindle density (IFGtri: β=0.238, P=0.019, and P.adjust=0.087; parietal: β=0.227, P=0.017, and P.adjust=0.082) and spindle duration (parietal: β=−0.230, P=0.013, and P.adjust=0.065). Attention Index Score (MoCA-AIS) was associated with spindle duration (IFGtri: β=−0.233, P=0.017, and P.adjust=0.081). Conclusions. The findings suggested that the altered spindle activity in epilepsy with severe cognitive impairment, the associations between the global cognitive status of adult epilepsy and spindle characteristics, and specific cognitive domains may relate to spindle characteristics in particular brain regions. |
| format | Article |
| id | doaj-art-e55ef81341ba4ae79eefd2f7cff4cb62 |
| institution | OA Journals |
| issn | 1687-5443 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e55ef81341ba4ae79eefd2f7cff4cb622025-08-20T02:21:18ZengWileyNeural Plasticity1687-54432023-01-01202310.1155/2023/7768980Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with EpilepsyYajin Huang0Yaqing Liu1Wenjun Song2Yanjun Liu3Xiaoqian Wang4Juping Han5Jiang Ye6Hongmei Han7Li Wang8Juan Li9Tiancheng Wang10The Second Clinical Medical CollegeDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyThe Second Clinical Medical CollegeThe Second Clinical Medical CollegeDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyObjective. Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy. Methods. Participants underwent one-night sleep electroencephalogram recording and neuropsychological tests on the same day. Spindle characteristics during N2 sleep were extracted using a learning-based system for sleep staging and an automated spindle detection algorithm. We investigated the difference between cognitive subgroups in spindle characteristics. Multiple linear regressions were applied to analyze associations between cognition and spindle characteristics. Results. Compared with no/mild cognitive impairment, epilepsy patients who developed severe cognitive impairment had lower sleep spindle density, the differences mainly distributed in central, occipital, parietal, middle temporal, and posterior temporal (P<0.05), and had relatively long spindle duration in occipital and posterior temporal P<0.05. Mini-Mental State Examination (MMSE) was associated with spindle density (pars triangularis of the inferior frontal gyrus (IFGtri): β=0.253, P=0.015, and P.adjust=0.074) and spindle duration (IFGtri: β=−0.262, P=0.004, and P.adjust=0.030). Montreal Cognitive Assessment (MoCA) was associated with spindle duration (IFGtri: β=−0.246, P=0.010, and P.adjust=0.055). Executive Index Score (MoCA-EIS) was associated with spindle density (IFGtri: β=0.238, P=0.019, and P.adjust=0.087; parietal: β=0.227, P=0.017, and P.adjust=0.082) and spindle duration (parietal: β=−0.230, P=0.013, and P.adjust=0.065). Attention Index Score (MoCA-AIS) was associated with spindle duration (IFGtri: β=−0.233, P=0.017, and P.adjust=0.081). Conclusions. The findings suggested that the altered spindle activity in epilepsy with severe cognitive impairment, the associations between the global cognitive status of adult epilepsy and spindle characteristics, and specific cognitive domains may relate to spindle characteristics in particular brain regions.http://dx.doi.org/10.1155/2023/7768980 |
| spellingShingle | Yajin Huang Yaqing Liu Wenjun Song Yanjun Liu Xiaoqian Wang Juping Han Jiang Ye Hongmei Han Li Wang Juan Li Tiancheng Wang Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy Neural Plasticity |
| title | Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy |
| title_full | Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy |
| title_fullStr | Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy |
| title_full_unstemmed | Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy |
| title_short | Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy |
| title_sort | assessment of cognitive function with sleep spindle characteristics in adults with epilepsy |
| url | http://dx.doi.org/10.1155/2023/7768980 |
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