Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome
Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel s...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2019/7890461 |
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| author | Yangzhi Xie Guijuan Zhou Yan Xu Bing He Yilin Wang Rundong Ma Yunqian Chang Duanqun He Chenlin Xu Zijian Xiao |
| author_facet | Yangzhi Xie Guijuan Zhou Yan Xu Bing He Yilin Wang Rundong Ma Yunqian Chang Duanqun He Chenlin Xu Zijian Xiao |
| author_sort | Yangzhi Xie |
| collection | DOAJ |
| description | Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of 60 patients diagnosed with migraine plus IBS were recruited for the study. IgG antibodies against 266 food varieties were detected by ELISA. Then, the subjects were randomized into three groups for treatment of IgG elimination diet or probiotics or diet combined with probiotics. Migraine symptom, gut function score, medication use, and serum serotonin level were measured at baseline, 7 weeks, and 14 weeks. Improvement of migraine and gut symptom was achieved at a certain time point. Reduced use of over-the-counter- (OTC−) analgesics was seen in all groups. However, use of triptans did not show significant difference. An increased serum serotonin level was seen in subjects treated with elimination diet and elimination diet combined with probiotics. IgG elimination diet combined with probiotics may be beneficial to migraine plus IBS. It may provide new insight by understanding the intricate relationship between migraine and gastrointestinal diseases. |
| format | Article |
| id | doaj-art-e55e40829eaf47e29323b22b104af985 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-e55e40829eaf47e29323b22b104af9852025-02-03T05:58:15ZengWileyPain Research and Management1203-67651918-15232019-01-01201910.1155/2019/78904617890461Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel SyndromeYangzhi Xie0Guijuan Zhou1Yan Xu2Bing He3Yilin Wang4Rundong Ma5Yunqian Chang6Duanqun He7Chenlin Xu8Zijian Xiao9The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, ChinaSeveral research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of 60 patients diagnosed with migraine plus IBS were recruited for the study. IgG antibodies against 266 food varieties were detected by ELISA. Then, the subjects were randomized into three groups for treatment of IgG elimination diet or probiotics or diet combined with probiotics. Migraine symptom, gut function score, medication use, and serum serotonin level were measured at baseline, 7 weeks, and 14 weeks. Improvement of migraine and gut symptom was achieved at a certain time point. Reduced use of over-the-counter- (OTC−) analgesics was seen in all groups. However, use of triptans did not show significant difference. An increased serum serotonin level was seen in subjects treated with elimination diet and elimination diet combined with probiotics. IgG elimination diet combined with probiotics may be beneficial to migraine plus IBS. It may provide new insight by understanding the intricate relationship between migraine and gastrointestinal diseases.http://dx.doi.org/10.1155/2019/7890461 |
| spellingShingle | Yangzhi Xie Guijuan Zhou Yan Xu Bing He Yilin Wang Rundong Ma Yunqian Chang Duanqun He Chenlin Xu Zijian Xiao Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome Pain Research and Management |
| title | Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome |
| title_full | Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome |
| title_fullStr | Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome |
| title_full_unstemmed | Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome |
| title_short | Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome |
| title_sort | effects of diet based on igg elimination combined with probiotics on migraine plus irritable bowel syndrome |
| url | http://dx.doi.org/10.1155/2019/7890461 |
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