Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases
Muscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory cells. Among these different cell types, macrophages emerged as a central actor coordinating the different cel...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/4761427 |
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| _version_ | 1832556510799986688 |
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| author | Junio Dort Paul Fabre Thomas Molina Nicolas A. Dumont |
| author_facet | Junio Dort Paul Fabre Thomas Molina Nicolas A. Dumont |
| author_sort | Junio Dort |
| collection | DOAJ |
| description | Muscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory cells. Among these different cell types, macrophages emerged as a central actor coordinating the different cellular interactions and biological processes. Particularly, the transition of macrophages from their proinflammatory to their anti-inflammatory phenotype was shown to regulate inflammation, myogenesis, fibrosis, vascularization, and return to homeostasis. On the other hand, deregulation of macrophage accumulation or polarization in chronic degenerative muscle disorders was shown to impair muscle regeneration. Considering the key roles of macrophages in skeletal muscle, they represent an attractive target for new therapeutic approaches aiming at mitigating various muscle disorders. This review aims at summarizing the novel insights into macrophage heterogeneity, plasticity, and functions in skeletal muscle homeostasis, regeneration, and disease. |
| format | Article |
| id | doaj-art-e55e2f12ce8840eca94b51347afb1833 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e55e2f12ce8840eca94b51347afb18332025-02-03T05:45:17ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/47614274761427Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and DiseasesJunio Dort0Paul Fabre1Thomas Molina2Nicolas A. Dumont3CHU Sainte-Justine Research Center, Montreal, QC, CanadaCHU Sainte-Justine Research Center, Montreal, QC, CanadaCHU Sainte-Justine Research Center, Montreal, QC, CanadaCHU Sainte-Justine Research Center, Montreal, QC, CanadaMuscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory cells. Among these different cell types, macrophages emerged as a central actor coordinating the different cellular interactions and biological processes. Particularly, the transition of macrophages from their proinflammatory to their anti-inflammatory phenotype was shown to regulate inflammation, myogenesis, fibrosis, vascularization, and return to homeostasis. On the other hand, deregulation of macrophage accumulation or polarization in chronic degenerative muscle disorders was shown to impair muscle regeneration. Considering the key roles of macrophages in skeletal muscle, they represent an attractive target for new therapeutic approaches aiming at mitigating various muscle disorders. This review aims at summarizing the novel insights into macrophage heterogeneity, plasticity, and functions in skeletal muscle homeostasis, regeneration, and disease.http://dx.doi.org/10.1155/2019/4761427 |
| spellingShingle | Junio Dort Paul Fabre Thomas Molina Nicolas A. Dumont Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases Stem Cells International |
| title | Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases |
| title_full | Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases |
| title_fullStr | Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases |
| title_full_unstemmed | Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases |
| title_short | Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases |
| title_sort | macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases |
| url | http://dx.doi.org/10.1155/2019/4761427 |
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